Evidence map›Paper›PMID 31217840›Full record

ArticleOxidative medicine and cellular longevity2019

TRPA1 Promotes Cardiac Myofibroblast Transdifferentiation after Myocardial Infarction Injury via the Calcineurin-NFAT-DYRK1A Signaling Pathway.

Shuang Li, Xiongshan Sun, Hao Wu, Peng Yu, Xin Wang, Zhenhua Jiang, Erhe Gao, Jiangwei Chen, De Li, Chenming Qiu and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. CaBiomedicines · 2025
    Review
  3. Review
  4. Review
  5. Research Progress on TRPA1 in Diseases.The Journal of membrane biology · 2023
    Review
  6. TRPA1 as Target in Myocardial Infarction.International journal of molecular sciences · 2023
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases.Oxidative medicine and cellular longevity · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Shuang LiDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.ORCID 0000-0002-6344-8377
Xiongshan SunDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.ORCID 0000-0002-7958-0620
Hao WuDepartment of Toxicology, The Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Shaanxi Key Laboratory of Free Radical Biology and Medicine, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.ORCID 0000-0003-4563-3365
Peng YuDepartment of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Xin WangDepartment of Toxicology, The Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Shaanxi Key Laboratory of Free Radical Biology and Medicine, School of Public Health, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.ORCID 0000-0002-7296-9406
Zhenhua JiangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Erhe GaoCenter of Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19107, USA.
Jiangwei ChenDepartment of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
De LiDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.
Chenming QiuDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.
Baomei SongDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.
Ken ChenDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.
Kecheng HeDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.
Dachun YangDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.ORCID 0000-0001-5462-2620
Yongjian YangDepartment of Cardiology, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu 610083, China.ORCID 0000-0003-1268-166X
Chengdu Military General Hospital · CNXijing Hospital · CNAir Force Medical University · CNTemple University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac fibroblasts (CFs) are a critical cell population responsible for myocardial extracellular matrix homeostasis. After stimulation by myocardial infarction (MI), CFs transdifferentiate into cardiac myofibroblasts (CMFs) and play a fundamental role in the fibrotic healing response. Transient receptor potential ankyrin 1 (TRPA1) channels are cationic ion channels with a high fractional Ca

Indexed as

AnimalsCalcineurinCell TransdifferentiationDisease Models, AnimalFibroblastsMaleMiceMyocardial InfarctionMyofibroblastsSignal TransductionTransfectionCalcineurin

Identifiers

PMID31217840
PMCPMC6537015
OpenAlexW2946126440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.