ArticleNature2019
A universal biomolecular integral feedback controller for robust perfect adaptation.
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
139 citing papers in PubMed, 394 citations in OpenAlex.
- GenAI-Net: A generative AI framework for automated biomolecular network design.Science advances · 2026Article
- Automated Classification of Homeostasis Structure in Input-Output Networks.Bulletin of mathematical biology · 2026Article
- Burden-aware feedback control of microbial consortia.Nature communications · 2026Article
- Signal Amplification in the HPT Axis-Evidence for Its Existence, Location, Significance, and Molecular Mechanisms.Acta physiologica (Oxford, England) · 2026Review
- Generative design of synthetic gene circuits for functional and evolutionary properties.NPJ systems biology and applications · 2026Article
- Review
- Programming Next-Generation Synthetic Biosensors by Genetic Circuit Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The adaptation property in non-equilibrium chemical systems.Journal of mathematical biology · 2026Article
- A recursive enzymatic competition network capable of multitask molecular information processing.Nature chemistry · 2026Article
- When prediction fails: a computational complexity view of stress.Frontiers in veterinary science · 2026Article
- PID-controller enhanced artificial β-cells.PloS one · 2026Article
- Tuning evolvability via plasmid copy number and regulatory architecture.Nature communications · 2025Article
- Toward single-cell control: noise-robust perfect adaptation in biomolecular systems.Nature communications · 2025Article
- Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems.Cell systems · 2025Review
- Article
- Article
- Cumulative dose responses for adapting biological systems.Journal of the Royal Society, Interface · 2025Article
- Article
- Article
- Topological criterion for robust perfect adaptation of reaction fluxes in biological networks.iScience · 2025Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Homeostasis is a recurring theme in biology that ensures that regulated variables robustly-and in some systems, completely-adapt to environmental perturbations. This robust perfect adaptation feature is achieved in natural circuits by using integral control, a negative feedback strategy that performs mathematical integration to achieve structurally robust regulation
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.