Evidence map›Paper›PMID 31217584›Full record

ArticleNature2019

Genetic analyses of diverse populations improves discovery for complex traits.

Genevieve L Wojcik, Mariaelisa Graff, Katherine K Nishimura, Ran Tao, Jeffrey Haessler, Christopher R Gignoux, Heather M Highland, Yesha M Patel, Elena P Sorokin, Christy L Avery and 76 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 654 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
654citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

654 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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594 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

86 authors.

Genevieve L WojcikDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Katherine K NishimuraDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ran TaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffrey HaesslerDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Christopher R GignouxDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yesha M PatelDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Elena P SorokinDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gillian M BelbinThe Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stephanie A BienDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Iona ChengDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Sinead CullinaThe Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chani J HodonskyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yao HuDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Laura M HuckinsPamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Janina JeffThe Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jonathan M KocarnikDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Unhee LimEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Bridget M LinDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yingchang LuThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sarah C NelsonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Sung-Shim L ParkDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hannah PoisnerThe Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael H PreussThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Melissa A RichardBrown Foundation Institute for Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA.
Claudia SchurmannThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Veronica W SetiawanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alexandra SockellDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Karan VahiInformation Sciences Institute, University of Southern California, Marina del Rey, CA, USA.
Marie VerbanckThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abhishek VishnuThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ryan W WalkerThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kristin L YoungDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Niha ZubairDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Victor Acuña-AlonsoEscuela Nacional de Antropologia e Historia, Mexico City, Mexico.
Jose Luis AmbiteInformation Sciences Institute, University of Southern California, Marina del Rey, CA, USA.
Kathleen C BarnesColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, The University of Texas Health Science Center, Houston, TX, USA.
Erwin P BottingerThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carlos D BustamanteDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Christian CabertoEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Samuel Canizales-QuinterosInstituto Nacional de Medicina Genómica, Mexico City, Mexico.
Matthew P ConomosDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Ewa DeelmanInformation Sciences Institute, University of Southern California, Marina del Rey, CA, USA.
Ron DoThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kimberly DohenyCenter for Inherited Disease Research, Johns Hopkins University, Baltimore, MD, USA.
Lindsay Fernández-RhodesDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Myriam FornageBrown Foundation Institute for Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA.
Benyam HailuNIH National Institute on Minority Health and Health Disparities, Bethesda, MD, USA.
Gerardo HeissDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Brenna M HennDepartment of Anthropology, University of California Davis, Davis, CA, USA.
Lucia A HindorffNIH National Human Genome Research Institute, Bethesda, MD, USA.
Rebecca D JacksonCenter for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA.
Cecelia A LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Yuqing LiDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Dan-Yu LinDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Andres Moreno-EstradaNational Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), Irapuato, Mexico.
Girish NadkarniThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Paul J NormanColorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Loreall C PoolerDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alexander P ReinerDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Jane RommCenter for Inherited Disease Research, Johns Hopkins University, Baltimore, MD, USA.
Chiara SabattiDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Karla SandovalNational Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), Irapuato, Mexico.
Xin ShengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Eli A StahlPamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Christina L WasselCollege of Medicine, University of Vermont, Burlington, VT, USA.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Cheryl A WinklerBasic Science Program, Frederick National Laboratory, Frederick, MD, USA.
Sachi YoneyamaDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Steven BuyskeDepartment of Statistics, Rutgers University, New Brunswick, NJ, USA.
Christopher A HaimanCenter for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Charles KooperbergDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Ruth J F LoosThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tara C MatiseDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ulrike PetersDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Eimear E KennyThe Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eimear.kenny@mssm.edu.
Christopher S CarlsonDivision of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ccarlson@fredhutch.org.

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
Statistical Methods for Cancer Clinical TrialsP01CA142538 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TSIATIS, ANASTASIOS A · 2010 to 2019
$21.3M
POPULATION STUDIEST32HD007168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELIZABETH A FRANKENBERG · 1985 to 2026
$13.8M
Institute of Translational Health SciencesKL2TR000421 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$12.6M
Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Genetics of Renal Disease in African AmericansZIABC010022 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$8.9M
NCATS NIH HHS KL2 TR000421NCATS NIH HHS KL2 TR001109NCI NIH HHS P01 CA142538NCI NIH HHS R01 CA082659NCI NIH HHS R25 CA094880NCI NIH HHS U01 CA164973NHGRI NIH HHS K22 HG000044NHGRI NIH HHS T32 HG000044NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHGRI NIH HHS U01 HG009080NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS K99 HL130580NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL104608NHLBI NIH HHS T32 HL007055NIA NIH HHS HHSN271201100004CNICHD NIH HHS P2C HD050924NICHD NIH HHS R24 HD050924NICHD NIH HHS T32 HD007168NICHD NIH HHS T32 HD049311NIDDK NIH HHS R01 DK101855NIGMS NIH HHS P01 GM099568NIGMS NIH HHS R01 GM047845NIMHD NIH HHS L60 MD008384WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on data from populations of European ancestry

Indexed as

Minority GroupsWomen's HealthAsian PeopleBlack or African AmericanBlack PeopleBody HeightCohort StudiesFemaleGenetics, MedicalGenome-Wide Association StudyHealth EquityHealth Status DisparitiesHispanic or LatinoHumansMaleMultifactorial Inheritance

Identifiers

PMID31217584
PMCPMC6785182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.