Evidence map›Paper›PMID 31217353›Full record

Trial reportJCI insight2019

Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss.

Parker N Hyde, Teryn N Sapper, Christopher D Crabtree, Richard A LaFountain, Madison L Bowling, Alex Buga, Brandon Fell, Fionn T McSwiney, Ryan M Dickerson, Vincent J Miller and 7 more

4 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JCI insight, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 117 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 6 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02918422 nacompletednot on this map

Controlled Feeding Study to Show Effects of Manipulating Carbohydrate and Cheese on Health Markers In Individuals With Metabolic Syndrome

TypeinterventionalSponsorOhio State UniversityRan2015 to 2018Enrolled16ConditionsMetabolic Syndrome XArmsNutritional and Dietary Manipulation
NCT05121844 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform: Comprehensive Weight Optimization Program and Customized Lifestyle Modifications

TypeinterventionalSponsorSignos IncRan2021 to 2027Enrolled31,187ConditionsWeight Loss, Metabolic Syndrome, Pre-diabetes, Central ObesityArmsContinuous Glucose Monitor Device
NCT05874635 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Use of Signos mHealth Platform in Participants With Non-Insulin Dependent Type 2 Diabetes: Weight and Blood Glucose

TypeinterventionalSponsorSignos IncRan2023 to 2029Enrolled20,000ConditionsWeight Loss, Metabolic Syndrome, Diabetes Mellitus, Type 2, Central ObesityArmsContinuous Glucose Monitor Device
NCT06214221 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

A Randomized Controlled Trial Evaluating the Safety and Effectiveness of the Intelligently-Driven Signos System for Personalized Weight Management in Overweight and Obese Adults

TypeinterventionalSponsorSignos IncRan2024 to 2026Enrolled380ConditionsOverweight and Obesity, Metabolic Syndrome, Weight LossArmsSignos System, Standard Lifestyle Education
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 6 syntheses or guidelines pooled it, 204 citations in OpenAlex.

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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Parker N HydeDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Teryn N SapperDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Christopher D CrabtreeDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Richard A LaFountainDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Madison L BowlingDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Alex BugaDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Brandon FellDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Fionn T McSwineyDepartment of Sport and Exercise Science, Waterford Institute of Technology, Waterford, Ireland.
Ryan M DickersonDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Vincent J MillerDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Debbie ScandlingDavis Heart & Lung Research Institute, Department of Radiology; Department of Internal Medicine, Division of Cardiovascular Medicine; Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Orlando P SimonettiDavis Heart & Lung Research Institute, Department of Radiology; Department of Internal Medicine, Division of Cardiovascular Medicine; Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Stephen D PhinneyVirta Health, San Francisco, California, USA.
William J KraemerDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
Sarah A KingDepartment of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.
Ronald M KraussDepartment of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.
Jeff S VolekDepartment of Human Sciences, The Ohio State University, Columbus, Ohio, USA.
The Ohio State University · USSutter Davis Hospital · USWaterford Institute of Technology · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUNDMetabolic syndrome (MetS) is highly correlated with obesity and cardiovascular risk, but the importance of dietary carbohydrate independent of weight loss in MetS treatment remains controversial. Here, we test the theory that dietary carbohydrate intolerance (i.e., the inability to process carbohydrate in a healthy manner) rather than obesity per se is a fundamental feature of MetS.METHODSIndividuals who were obese with a diagnosis of MetS were fed three 4-week weight-maintenance diets that were low, moderate, and high in carbohydrate. Protein was constant and fat was exchanged isocalorically for carbohydrate across all diets.RESULTSDespite maintaining body mass, low-carbohydrate (LC) intake enhanced fat oxidation and was more effective in reversing MetS, especially high triglycerides, low HDL-C, and the small LDL subclass phenotype. Carbohydrate restriction also improved abnormal fatty acid composition, an emerging MetS feature. Despite containing 2.5 times more saturated fat than the high-carbohydrate diet, an LC diet decreased plasma total saturated fat and palmitoleate and increased arachidonate.CONCLUSIONConsistent with the perspective that MetS is a pathologic state that manifests as dietary carbohydrate intolerance, these results show that compared with eucaloric high-carbohydrate intake, LC/high-fat diets benefit MetS independent of whole-body or fat mass.TRIAL REGISTRATIONClinicalTrials.gov Identifier: NCT02918422.FUNDINGDairy Management Inc. and the Dutch Dairy Association.

Indexed as

Weight Loss8,11,14-Eicosatrienoic AcidAdultAgedArachidonic AcidCholesterol, LDLCross-Over StudiesDietDietary CarbohydratesFemaleHumansMaleMetabolic SyndromeMiddle AgedObesity8,11,14-Eicosatrienoic AcidArachidonic AcidCholesterol, LDLDietary CarbohydratesLipoproteinsMetabolismObesity

Identifiers

PMID31217353
PMCPMC6629108
OpenAlexW2952929143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.