Evidence map›Paper›PMID 31217332›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.

Sylvia Ortega-Martinez, Nisha Palla, Xiaoqiong Zhang, Erin Lipman, Sangram S Sisodia

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Adult Neurogenesis, Learning and Memory.Advances in neurobiology · 2024
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Microglia in the developing retina.Neural development · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Sylvia Ortega-MartinezDepartments of Neurobiology.
Nisha PallaB.A. Neuroscience, and.
Xiaoqiong ZhangDepartments of Neurobiology.
Erin LipmanStatistics, The University of Chicago, Chicago, Illinois 60637.
Sangram S SisodiaDepartments of Neurobiology, ssisodia@bsd.uchicago.edu.
Institute of Neurobiology · BGInstitut des Sciences Cognitives Marc Jeannerod · FRUniversity of Chicago · US

Funding

Presenilin Variants in the Modulation of Hippocampal NeurogenesisR01AG040185 · NIA · UNIVERSITY OF CHICAGO · PI SISODIA, SANGRAM S. · 2011 to 2020
$4.7M
Modulation of ABeta Deposition by Environmental EnrichmentR01AG027854 · NIA · UNIVERSITY OF CHICAGO · PI SISODIA, SANGRAM S. · 2007 to 2011
$2.0M
NIA NIH HHS R01 AG027854NIA NIH HHS R01 AG040185
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that presently affects an estimated 5.7 million Americans. Understanding the basis for this disease is key for the development of a future successful treatment. In this effort, we previously reported that mouse prion protein-promoter-driven, ubiquitous expression of familial AD (FAD)-linked human

Indexed as

EnvironmentAlzheimer DiseaseAnimalsAnxietyBehavior, AnimalCell DifferentiationCell ProliferationCell SurvivalHippocampusHumansMacrophage Colony-Stimulating FactorMaleMiceMice, Inbred C57BLMice, TransgenicMicrogliaCSF1 protein, mouseMacrophage Colony-Stimulating FactorOrganic ChemicalsPLX5622Presenilin-1PSEN1 protein, humanAlzheimeranxiety behaviorsenvironmental enrichmenthippocampal neurogenesismicrogliapresenilin

Identifiers

PMID31217332
PMCPMC6703877
OpenAlexW2952366162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.