ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Targeted plasma proteomics uncover proteins associated with KIF5A-linked SPG10 and ALS spectrum disorders.HGG advances · 2026Article
- Co-release of GABA and ACh from Medial Olivocochlear Neurons as a Fine Regulatory Mechanism of Cochlear Efferent Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Medial olivocochlear reflex dysfunction in multiple sclerosis: The influence of brainstem lesion localization and its clinical implications.World journal of clinical cases · 2025Article
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pre-Sensory Spontaneous Activity Accelerates Coordinated Maturation of Synaptic Partners and Drives Transition to the Mature Physiological Phenotype.bioRxiv : the preprint server for biology · 2025Article
- Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.bioRxiv : the preprint server for biology · 2025Article
- Impacts of perinatal nicotine exposure on nicotinic acetylcholine receptor expression and glutamatergic synaptic transmission in the mouse auditory brainstem.The Journal of physiology · 2025Article
- Co-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition.bioRxiv : the preprint server for biology · 2024Article
- Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.Trends in neurosciences · 2024Review
- Genetic tools for studying cochlear inhibition.Frontiers in cellular neuroscience · 2024Review
- Engineering olivocochlear inhibition to reduce acoustic trauma.Molecular therapy. Methods & clinical development · 2023Article
- Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice.The Journal of comparative neurology · 2022Article
- Developmental spontaneous activity promotes formation of sensory domains, frequency tuning and proper gain in central auditory circuits.Cell reports · 2022Article
- Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem.Frontiers in cellular neuroscience · 2022Article
- Neurovascular responses to neuronal activity during sensory development.Frontiers in cellular neuroscience · 2022Article
- CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem.The Journal of comparative neurology · 2021Article
- Efferent feedback controls bilateral auditory spontaneous activity.Nature communications · 2021Article
- Intrinsic burst-firing in lamina I spinoparabrachial neurons during adolescence.Neuroscience letters · 2021Article
- Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Characterization of Developmental Changes in Spontaneous Electrical Activity of Medial Superior Olivary Neurons Before Hearing Onset With a Combination of Injectable and Volatile Anesthesia.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The auditory system in many mammals is immature at birth but precisely organized in adults. Spontaneous activity in the inner ear plays a critical role in guiding this maturation process. This is shaped by an efferent pathway that descends from the brainstem and makes transient direct synaptic contacts with inner hair cells. In this work, we used an α9 cholinergic nicotinic receptor knock-in mouse model (of either sex) with enhanced medial efferent activity (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.