Evidence map›Paper›PMID 31217325›Full record

ArticleJournal of the American Society of Nephrology : JASN2019

Osmoregulation Performance and Kidney Transplant Outcome.

Manal Mazloum, Jordan Jouffroy, François Brazier, Christophe Legendre, Antoine Neuraz, Nicolas Garcelon, Dominique Prié, Dany Anglicheau, Frank Bienaimé

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. A "Set Point" for Water Homeostasis Disturbed with Altered Kidney Transplantation Outcome.Journal of the American Society of Nephrology : JASN · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Manal MazloumService de Department of Nephrology and Kidney Transplantation.
Jordan JouffroyMedical Faculty, Paris University, Paris, France.
François BrazierMedical Faculty, Paris University, Paris, France.
Christophe LegendreService de Department of Nephrology and Kidney Transplantation.
Antoine NeurazMedical Faculty, Paris University, Paris, France.ORCID 0000-0001-7142-6728
Nicolas GarcelonImagine Institute, Paris, France.
Dominique PriéMedical Faculty, Paris University, Paris, France.
Dany AnglicheauService de Department of Nephrology and Kidney Transplantation.ORCID 0000-0001-5793-6174
Frank BienaiméMedical Faculty, Paris University, Paris, France; frank.bienaime@inserm.fr.ORCID 0000-0002-8666-2042
Inserm · FRInstitut des Maladies Génétiques Imagine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplant recipients have an impaired ability to dilute urine but seldom develop baseline hyponatremia before ESRD. Although hyponatremia is a risk factor for adverse events in CKD and in kidney transplant recipients, it remains unclear whether subtler alterations in osmoregulation performance are associated with outcome.

methodsWe studied a single-center prospective cohort of 1258 kidney transplant recipients who underwent a water-loading test 3 months after transplant to determine osmoregulation performance. Measured GFR (mGFR) was performed at the same visit. A group of 164 healthy candidates for kidney donation served as controls. We further evaluated the association of osmoregulation performance with transplantation outcomes and subsequent kidney function.

resultsUnlike controls, most kidney transplant recipients failed to maintain plasma sodium during water loading (plasma sodium slope of -0.6±0.4 mmol/L per hour in transplant recipients versus -0.12±0.3 mmol/L per hour in controls;

conclusionsReduced osmoregulation performance occurs frequently in kidney transplant recipients and is an independent predictor of renal outcome.

Indexed as

Kidney TransplantationOsmoregulationGlomerular Filtration RateHumansProspective StudiesSodiumTransplantation, HomologousSodiumkidney transplantationosmoregulationSodium

Identifiers

PMID31217325
PMCPMC6622417
OpenAlexW2951100647

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.