Evidence map›Paper›PMID 31217274›Full record

ArticleJournal of clinical microbiology2019

Viruses in Vietnamese Patients Presenting with Community-Acquired Sepsis of Unknown Cause.

Nguyen To Anh, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Tran Tan Thanh, Chuen-Yen Lau, Direk Limmathurotsakul, Xutao Deng, Motiur Rahman, Nguyen Van Vinh Chau, H Rogier van Doorn and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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  11. Viruses · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Nguyen To AnhOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam anhnt@oucru.org tanlv@oucru.org.
Nguyen Thi Thu HongOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Le Nguyen Truc NhuOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Tran Tan ThanhOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Chuen-Yen LauCollaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Direk LimmathurotsakulCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Xutao DengBlood Systems Research Institute, San Francisco, California, USA.
Motiur RahmanOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.ORCID 0000-0002-6702-5355
Nguyen Van Vinh ChauHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
H Rogier van DoornOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Guy ThwaitesOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Eric DelwartBlood Systems Research Institute, San Francisco, California, USA.ORCID 0000-0002-6296-4484
Le Van TanOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam anhnt@oucru.org tanlv@oucru.org.
Oxford University Clinical Research Unit · VNUniversity of Oxford · GBUniversity of California, San Francisco · USHospital for Tropical Diseases · VNNational Institutes of Health · US

Funding

Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENHLBI NIH HHS R01 HL105770Wellcome Trust
6 · The paper itself

Abstract

Community-acquired (CA) sepsis is a major public health problem worldwide, yet the etiology remains unknown for >50% of the patients. Here we applied metagenomic next-generation sequencing (mNGS) to characterize the human virome in 492 clinical samples (384 sera, 92 pooled nasal and throat swabs, 10 stools, and 6 cerebrospinal fluid samples) from 386 patients (213 adults and 173 children) presenting with CA sepsis who were recruited from 6 hospitals across Vietnam between 2013 and 2015. Specific monoplex PCRs were used subsequently to confirm the presence of viral sequences detected by mNGS. We found sequences related to 47 viral species belonging to 21 families in 358 of 386 (93%) patients, including viruses known to cause human infections. After PCR confirmation, human viruses were found in 52 of 386 patients (13.4%); picornavirus (enteroviruses [

Indexed as

AdolescentAdultAgedAged, 80 and overAsian PeopleChildChild, PreschoolCommunity-Acquired InfectionsFemaleHigh-Throughput Nucleotide SequencingHospitalsHumansInfantInfant, NewbornMaleMetagenomicscommunity-acquired sepsisVietnamviral metagenomics

Identifiers

PMID31217274
PMCPMC6711913
OpenAlexW2952339892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.