Evidence map›Paper›PMID 31217270›Full record

ArticleJournal of clinical microbiology2019

Decreased Seroreactivity in Individuals Initiating Antiretroviral Therapy during Acute HIV Infection.

Mark M Manak, Linda L Jagodzinski, Ashley Shutt, Jennifer A Malia, Mike Leos, Jason Ouellette, Siriwat Akapirat, Donn L Colby, Nittaya Phanuphak, Leigh Anne Eller and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Suppressed HIV antibody responses following exposure to antiretrovirals-evidence from PrEP randomized trials and early antiretroviral treatment initiation studies.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  6. Article
  7. Article
  8. Observational
  9. Novel Criteria for Diagnosing Acute and Early Human Immunodeficiency Virus Infection in a Multinational Study of Early Antiretroviral Therapy Initiation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Hindsight Is 2019-the Year in Clinical Microbiology.Clinical microbiology newsletter · 2020
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Mark M ManakU.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.ORCID 0000-0002-9217-9129
Linda L JagodzinskiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA ljagodzinski@hivresearch.org.
Ashley ShuttU.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
Jennifer A MaliaU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Mike LeosBio-Rad Laboratories, Inc., Benicia, California, USA.
Jason OuelletteU.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
Siriwat AkapiratDepartment of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Donn L ColbySEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Nittaya PhanuphakSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Leigh Anne EllerU.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
Merlin L RobbU.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
Mark de SouzaSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Jintanat AnanworanichU.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
Sheila A Peel
RV254/SEARCH010 and the RV217 Study Teams
Henry M. Jackson Foundation · USThai Red Cross Society · THWalter Reed Army Institute of Research · USArmed Forces Research Institute of Medical Science · THBio-Rad (United States) · US

Funding

Preservation of adaptive immunity leads to HIV control upon treatment cessation.R01AI108433 · NIAID · VGTI FLORIDA · PI VASAN, SANDHYA · 2014 to 2018
$3.6M
NIAID NIH HHS R01 AI108433
6 · The paper itself

Abstract

Antiretroviral therapy (ART) during acute HIV infection (AHI) interrupts viral dynamics and may delay the emergence of serological markers targeted by current HIV screening and confirmatory assays, thus creating challenges for correctly classifying HIV infection status. The performance of three HIV antigen/antibody combination (HIV Ag/Ab Combo) assays (the Bio-Rad GS, Abbott Architect, and Bio-Rad BioPlex 2200 assays) was evaluated with samples collected from RV254/South East Asia Research Collaboration in HIV 010 (RV254/SEARCH010) study (Bangkok, Thailand) participants at weeks 12 and 24 following the initiation of ART at Fiebig stage I (FI) (

Indexed as

HIVAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveFemaleHIV AntibodiesHIV AntigensHIV InfectionsHIV SeropositivityHumansImmunoassayMaleRNA, ViralSerologic TestsTreatment OutcomeAnti-HIV AgentsHIV AntibodiesHIV AntigensRNA, Viralacute HIV infectionantiretroviral therapyHIV Ag/Ab Combo assayHIV Geenius assayhuman immunodeficiency virusimmunodiagnosticsseroreversion

Identifiers

PMID31217270
PMCPMC6760936
OpenAlexW2950612413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.