SynthesisJournal of medical genetics2019
Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns.
Synthesis in Journal of medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes: a prospective study in three independent cohorts.BMJ open diabetes research & care · 2022Pooled it
- Association between ABO and Duffy blood types and circulating chemokines and cytokines.Genes and immunity · 2021Trial
- Genome-wide association study reveals loci associated with cytokine levels in chicken serum.Poultry science · 2026Article
- Inflammageing, a targetable pathway for preventing cardiovascular diseases.Cardiovascular research · 2025Review
- VEGF-A cis-located SNPs on human chromosome 6 associated with VEGF-A plasma levels and survival in a coronary disease cohort.BMC cardiovascular disorders · 2025Article
- A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases.Translational psychiatry · 2025Article
- Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19.iScience · 2024Article
- Circulating levels of cytokines and risk of urologic cancers: a two-sample Mendelian randomization study.BMC cancer · 2024Article
- Common variation in a long non-coding RNA gene modulates variation of circulating TGF-β2 levels in metastatic colorectal cancer patients (Alliance).BMC genomics · 2024Article
- A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases.medRxiv : the preprint server for health sciences · 2024Article
- Genomic analysis of venous thrombosis in children with acute lymphoblastic leukemia from diverse ancestries.Haematologica · 2024Article
- Circulating inflammatory cytokines in relation to the risk of renal cell carcinoma: A gender-specific two-sample Mendelian randomization study.Cancer medicine · 2023Article
- Whole-Exome Sequencing in Family Trios Reveals De Novo Mutations Associated with Type 1 Diabetes Mellitus.Biology · 2023Article
- The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study.BMJ medicine · 2023Article
- Ten interleukins and risk of prostate cancer.Frontiers in oncology · 2023Article
- Connecting aging biology and inflammation in the omics era.The Journal of clinical investigation · 2022Review
- Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.PLoS genetics · 2022Article
- The prognostic value of circulating lymphocyte counts and ABO blood group in lung cancer stereotactic body radiation therapy: a retrospective study.Journal of thoracic disease · 2022Article
- Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis.BMC medicine · 2022Article
- Human immune diversity: from evolution to modernity.Nature immunology · 2021Review
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating the inflammatory load, but the exact mechanisms are incompletely understood.
objectiveTo assess genetic determinants of 16 circulating cytokines and cell adhesion molecules (inflammatory phenotypes) in Finns.
methodsGenome-wide associations of the inflammatory phenotypes were studied in Northern Finland Birth Cohort 1966 (N=5284). A subsequent meta-analysis was completed for 10 phenotypes available in a previous genome-wide association study, adding up to 13 577 individuals in the study. Complementary association tests were performed to study the effect of the ABO blood types on soluble adhesion molecule levels.
resultsWe identified seven novel and six previously reported genetic associations (p<3.1×10
conclusionThe present results extend the knowledge about genetic factors contributing to the inflammatory load. Our findings suggest that two distinct mechanisms contribute to the soluble adhesion molecule levels in the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.