ArticleJournal of virology2019
Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8
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Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
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- Role of mucosal chemokines in the development of tissue-resident CD4Frontiers in immunology · 2026Review
- The Path Towards Effective Long-Lasting Tissue-Targeted Prime/Pull/Keep Herpes Simplex Therapeutic Vaccines.Vaccines · 2025Review
- Host-virus interactions during infection with a wild-type ILTV strain or a glycoprotein G deletion mutant ILTV vaccine strain in anMicrobiology spectrum · 2025Article
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- Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.Frontiers in immunology · 2023Article
- T-cells in human trigeminal ganglia express canonical tissue-resident memory T-cell markers.Journal of neuroinflammation · 2022Article
- Cutting-Edge: Preclinical and Clinical Development of the First Approved Lag-3 Inhibitor.Cells · 2022Review
- Antiviral CD19Journal of virology · 2022Article
- The immune-suppressive landscape in lepromatous leprosy revealed by single-cell RNA sequencing.Cell discovery · 2022Article
- Rabbit VX2 Liver Tumor Model: A Review of Clinical, Biology, Histology, and Tumor Microenvironment Characteristics.Frontiers in oncology · 2022Review
- Understanding LAG-3 Signaling.International journal of molecular sciences · 2021Review
- PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy.Oncoimmunology · 2021Article
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- Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research.Frontiers in genetics · 2021Review
- Detection of Immune Checkpoint Receptors - A Current Challenge in Clinical Flow Cytometry.Frontiers in immunology · 2021Review
- Local Immune Control of Latent Herpes Simplex Virus Type 1 in Ganglia of Mice and Man.Frontiers in immunology · 2021Review
- Tissue-Resident Memory T Cells in Antifungal Immunity.Frontiers in immunology · 2021Review
- Herpes Simplex Virus 1 (HSV-1) 0ΔNLS Live-Attenuated Vaccine Protects against Ocular HSV-1 Infection in the Absence of Neutralizing Antibody in HSV-1 gB T Cell Receptor-Specific Transgenic Mice.Journal of virology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Soumyabrata RoyLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Pierre-Gregoire CoulonLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Swayam PrakashLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Ruchi SrivastavaLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Roger GeertsemaUniversity Laboratory Animal Resources, University of California-Irvine, Irvine, California, USA.
Nisha DhanushkodiLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Cynthia LamLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Vivianna NguyenLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Elyssa GorospeLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Angela M NguyenLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Stephanie SalazarLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Nuha I AlomariLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Wasay R WarsiLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA.
Lbachir BenMohamedLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, Irvine, California, USA Lbenmoha@uci.edu.
University of California, Irvine · US
Funding
Therapeutic Ocular HSV Vaccine in HLA Transgenic RabbitsR01EY019896 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2010 to 2025
$5.1MA Novel Prime/Pull Therapeutic Vaccine Strategy to Prevent Recurrent Genital HerpesR01AI150091 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Lbachir BenMohamed · 2020 to 2026
$4.0MDeveloping a Multi-epitope Pan-Coronavirus VaccineR01AI158060 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2020 to 2024
$3.7MMucosal Chemokines and CD8+ T Cell Immunity to Genital HerpesR01AI143348 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2019 to 2022
$2.4MMechanisms of CD8+ T Cell Dynamics in Recurrent Ocular Herpetic DiseaseR01EY026103 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2016 to 2019
$1.5MBlockade of T-cell Co-Inhibitory Pathways & Immunotherapy to Prevent Ocular HerpeR01EY024618 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2014 to 2016
$1.2MImpact of Immune Checkpoints Blockade on HSV-1 Neuro-PathogenesisR21AI143326 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2019 to 2020
$464kLAT-HVEM Interactions Effect HSV-1 Latency/ReactivationR21AI110902 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2015 to 2016
$425kPROTECTIVE IMMUNITY AGAINST RECURRENT OCULAR HERPES INDUCED WITH SELF-ASSEMBLING PROTEIN NANOPARTICLESR21AI147499 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BENMOHAMED, LBACHIR · 2019 to 2020
$399kA NOVEL SELF-ASSEMBLING PROTEIN NANOPARTICLES-BASED GENITAL HERPES VACCINER41AI138764 · NIAID · SUNOMIX THERAPEUTICS · PI BENMOHAMED, LBACHIR · 2018 to 2018
$236kNEI NIH HHS R01 EY019896NEI NIH HHS R01 EY024618NEI NIH HHS R01 EY026103NIAID NIH HHS R01 AI143348NIAID NIH HHS R01 AI150091NIAID NIH HHS R01 AI158060NIAID NIH HHS R21 AI110902NIAID NIH HHS R21 AI143326NIAID NIH HHS R21 AI147499NIAID NIH HHS R41 AI138764
Abstract
Chronic viruses such as herpes simplex virus 1 (HSV-1) evade the hosts' immune system by inducing the exhaustion of antiviral T cells. In the present study, we found that exhausted HSV-specific CD8
Indexed as
AdultAnimalsAntigens, CDB7-H1 AntigenCD8-Positive T-LymphocytesCorneaEpitopes, T-LymphocyteFemaleHerpes Simplex Virus VaccinesHerpesvirus 1, HumanHistocompatibility AntigensHistocompatibility Antigens Class IIHLA-A2 AntigenHLA AntigensHumansImmunizationAntigens, CDB7-H1 AntigenCD274 protein, humanEpitopes, T-LymphocyteHerpes Simplex Virus VaccinesHistocompatibility AntigensHistocompatibility Antigens Class IIHLA-A2 AntigenHLA AntigensLymphocyte Activation Gene 3 ProteinProgrammed Cell Death 1 ReceptorCD8+ T celldiseaseherpesHSV-1LAG-3ocularPD-1protectionrabbitvaccine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.