ArticleJournal of virology2019
Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology.
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In one paragraph
Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 37 citations in OpenAlex.
- Engineering Protein-Based HIV Entry Inhibitors: Advances, Challenges, and Translational Strategies.Biomolecules · 2026Review
- Extended hinge length of human IgG3-like antibody enhances early antiviral activity of VRC01 in SHIV-infected rhesus macaques.Journal of virology · 2026Article
- Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates.Journal of virology · 2026Article
- Gastrointestinal Mucosal Disruptions During ART-Treated SIVPathogens & immunity · 2026Article
- Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption.Science translational medicine · 2025Article
- Isolation and structure of broad SIV-neutralizing antibodies reveal a proximal helical MPER epitope recognized by a rhesus multi-donor class.Cell reports · 2025Article
- Article
- SHIV-C109p5 NHP induces rapid disease progression in elderly macaques with extensive GI viral replication.Journal of virology · 2024Article
- Article
- Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The IL-17 family in diseases: from bench to bedside.Signal transduction and targeted therapy · 2023Review
- Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques.Retrovirology · 2023Article
- Advances in HIV therapeutics and cure strategies: findings obtained through non-human primate studies.Journal of neurovirology · 2023Review
- Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques.PLoS pathogens · 2023Article
- Probiotic Therapy During Vaccination Alters Antibody Response to Simian-Human Immunodeficiency Virus Infection But Not to Commensals.AIDS research and human retroviruses · 2023Article
- Article
- Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infection.Journal of neuroinflammation · 2022Article
- Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain.Cells · 2022Article
- So Pathogenic or So What?-A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research.Viruses · 2022Review
- Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 1 country.
Katharine J BarDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ernesto CoronadoDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Tiffany Hensley-McBainDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Megan A O'ConnorWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Jessica M OsbornWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Charlene MillerDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Toni M GottDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Solomon WangariWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Naoto IwayamaWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Chul Y AhrensWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Jeremy SmedleyWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Cassie MoatsWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Rebecca M LynchDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Elias K HaddadDivision of Infectious Diseases & HIV Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Nancy L HaigwoodOregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon, USA.
Deborah H FullerWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
George M ShawDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nichole R KlattDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Jennifer A ManuzakDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA jmanuzak@med.miami.edu.ORCID 0000-0002-0079-2306
University of Washington · USOregon National Primate Research Center · USUniversity of Miami · USUniversity of Pennsylvania · USDrexel University · USGeorge Washington University · US
Funding
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI MCMICHAEL, ANDREW JAMES · 2012 to 2018
$204.7MUpgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MWashington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8MVirus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6MVirus and Antibody Gene Sequencing CoreP01AI131251 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GEORGE M SHAW · 2017 to 2026
$40.7MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MCollaboratory of AIDS Researchers for Eradication (CARE)UM1AI126619 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARGOLIS, DAVID M. · 2016 to 2020
$23.2MVENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4MViral Testing CoreU42OD010426 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Gregory A Dissen · 2013 to 2026
$6.0MPersistent modulation of microbiota to enhance HIV vaccinationR01AI120712 · NIAID · UNIVERSITY OF WASHINGTON · PI KLATT, NICHOLE ROSE · 2015 to 2019
$4.0MTargeting 5' leader-encoded defective ribosomal products for HIV T cell vaccinesR01AI118549 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHAW, GEORGE M · 2016 to 2020
$3.6MbNAb induction by antigenically diverse V1V2 lineage specific SHIVs and SOSIPsR01AI131331 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHAW, GEORGE M · 2017 to 2020
$3.2MNIAID NIH HHS P01 AI131251NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI118549NIAID NIH HHS R01 AI120712NIAID NIH HHS R01 AI131331NIAID NIH HHS T32 AI007140NIAID NIH HHS UM1 AI100645NIAID NIH HHS UM1 AI126619NIAID NIH HHS UM1 AI126620NIH HHS K01 OD024876NIH HHS P51 OD010425NIH HHS P51 OD011092NIH HHS U42 OD010426
Abstract
Simian-human immunodeficiency viruses (SHIVs) have been utilized to test vaccine efficacy and characterize mechanisms of viral transmission and pathogenesis. However, the majority of SHIVs currently available have significant limitations in that they were developed using sequences from chronically HIV-infected individuals or uncommon HIV subtypes or were optimized for the macaque model by serially passaging the engineered virus
Indexed as
AnimalsDisease Models, Animalenv Gene Products, Human Immunodeficiency VirusGenetic EngineeringHIVHIV-1HIV InfectionsHumansIntestinal MucosaMacaca mulattaModels, BiologicalSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadVirus Replicationenv Gene Products, Human Immunodeficiency Virusgp140 envelope protein, Human immunodeficiency virus 1immunopathogenesismucosal immunitynonhuman primateSHIV
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.