Evidence map›Paper›PMID 31217248›Full record

ArticleJournal of virology2019

A Hydrophobic Target: Using the Paramyxovirus Fusion Protein Transmembrane Domain To Modulate Fusion Protein Stability.

Chelsea T Barrett, Stacy R Webb, Rebecca Ellis Dutch

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Antivirals targeting paramyxovirus membrane fusion.Current opinion in virology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chelsea T Barrett *Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.
Stacy R Webb *Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.
Rebecca Ellis DutchDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA rdutc2@uky.edu.
University of Kentucky · US

Funding

SV5 and Hendra virus F protein promoted membrane fusionR01AI051517 · NIAID · UNIVERSITY OF KENTUCKY · PI DUTCH, REBECCA E. · 2002 to 2019
$4.4M
Fusion protein TM-TM interactions: Modulation of pre-fusion protein stabilityF31AI120653 · NIAID · UNIVERSITY OF KENTUCKY · PI WEBB, STACY RENEE · 2015 to 2016
$69k
NIAID NIH HHS F31 AI120653NIAID NIH HHS R01 AI051517
6 · The paper itself

Abstract

Enveloped viruses utilize surface glycoproteins to bind and fuse with a target cell membrane. The zoonotic Hendra virus (HeV), a member of the family

Indexed as

AnimalsBinding SitesChlorocebus aethiopsHendra VirusHydrophobic and Hydrophilic InteractionsParainfluenza Virus 5ParamyxovirinaePeptidesProtein ConformationProtein DomainsProtein StabilityVero CellsViral Fusion ProteinsPeptidesViral Fusion Proteinsantiviral agentsfusion proteinmembrane fusiontransmembrane domain

Identifiers

PMID31217248
PMCPMC6694835
OpenAlexW2950444065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.