Evidence map›Paper›PMID 31217192›Full record

ArticleThe Journal of experimental medicine2019

The epigenetic regulator ATF7ip inhibits

Jun Hyung Sin, Cassandra Zuckerman, Jessica T Cortez, Walter L Eckalbar, David J Erle, Mark S Anderson, Michael R Waterfield

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
  8. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jun Hyung SinDiabetes Center, University of California, San Francisco, San Francisco, CA.
Cassandra ZuckermanDiabetes Center, University of California, San Francisco, San Francisco, CA.
Jessica T CortezDiabetes Center, University of California, San Francisco, San Francisco, CA.ORCID 0000-0002-6314-7267
Walter L EckalbarDepartment of Medicine, University of California San Francisco, San Francisco, CA.
David J ErleDepartment of Medicine, University of California San Francisco, San Francisco, CA.
Mark S AndersonDiabetes Center, University of California, San Francisco, San Francisco, CA mark.anderson@ucsf.edu.
Michael R WaterfieldDiabetes Center, University of California, San Francisco, San Francisco, CA michael.waterfield@ucsf.edu.ORCID 0000-0003-1950-9379
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Thymic medullary epithelial cell turnover and control of immune toleranceR37AI097457 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark S Anderson · 2017 to 2026
$4.0M
Using human stem cell-derived thymic epithelium to remodel T1D immune toleranceU01DK107383 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S, BLUESTONE, JEFFREY A · 2016 to 2019
$2.3M
Coopting epigenetic regulators by Aire to maintain immune toleranceK08AI121513 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WATERFIELD, MICHAEL R · 2016 to 2020
$1.1M
BD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573k
NIAID NIH HHS K08 AI121513NIAID NIH HHS R37 AI097457NIDDK NIH HHS P30 DK063720NIDDK NIH HHS U01 DK107383NIH HHS S10 OD021822
6 · The paper itself

Abstract

T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically. Due to the role of Th17 cells in autoimmune pathogenesis, it is important to understand the factors that control Th17 development. Here we identify the activating transcription factor 7 interacting protein (ATF7ip) as a critical regulator of Th17 differentiation. Mice with T cell-specific deletion of

Indexed as

Epigenesis, GeneticAnimalsCell DifferentiationColitisDNA, IntergenicHistonesInterleukin-2LysineMethylationMice, Inbred C57BLReceptors, Antigen, T-CellRepressor ProteinsTh17 CellsAtf7ip protein, mouseDNA, IntergenicHistonesInterleukin-2LysineReceptors, Antigen, T-CellRepressor Proteins

Identifiers

PMID31217192
PMCPMC6719416
OpenAlexW2951798762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.