Evidence map›Paper›PMID 31217176›Full record

Trial reportDiabetes2019

Immune Complexes and the Risk of CVD in Type 1 Diabetes.

Maria F Lopes-Virella, Ionut Bebu, Kelly J Hunt, Gabriel Virella, Nathaniel L Baker, Barbara Braffett, Xiaoyu Gao, John M Lachin, DCCT/EDIC Research Group

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maria F Lopes-VirellaMedical University of South Carolina, Charleston, SC.ORCID 0000-0001-5572-1700
Ionut BebuBiostatistics Center, The George Washington University, Rockville, MD.ORCID 0000-0002-4944-7968
Kelly J HuntMedical University of South Carolina, Charleston, SC.ORCID 0000-0001-8999-3587
Gabriel VirellaMedical University of South Carolina, Charleston, SC.
Nathaniel L BakerMedical University of South Carolina, Charleston, SC.ORCID 0000-0003-3313-1579
Barbara BraffettBiostatistics Center, The George Washington University, Rockville, MD.ORCID 0000-0002-2184-9754
Xiaoyu GaoBiostatistics Center, The George Washington University, Rockville, MD.
John M LachinBiostatistics Center, The George Washington University, Rockville, MD jml@bsc.gwu.edu.ORCID 0000-0001-9838-2841
DCCT/EDIC Research Group
George Washington University · USMedical University of South Carolina · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

We investigated whether the composition of modified forms of LDL in circulating immune complexes (LDL-ICs) was associated with cardiovascular disease (CVD) outcomes, including any CVD, major adverse cardiac and cerebrovascular events (MACCE), myocardial infarction (MI), and coronary artery disease, in type 1 diabetes (T1D). Our results demonstrate that the baseline levels of oxidized LDL (oxLDL), MDA-modified LDL (MDA-LDL), and advanced glycosylation-modified LDL (AGE-LDL) in circulating ICs were associated with the four CVD outcomes in unadjusted models, and adjustment by age and mean HbA

Indexed as

Antigen-Antibody ComplexAdolescentAdultBiomarkersCardiovascular DiseasesDiabetes Mellitus, Type 1FemaleGlycation End Products, AdvancedHumansLipoproteins, LDLMaleRisk FactorsYoung AdultAntigen-Antibody ComplexBiomarkersGlycation End Products, AdvancedLipoproteins, LDL

Identifiers

PMID31217176
PMCPMC6702641
OpenAlexW2949132973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.