ArticleCancer imaging : the official publication of the International Cancer Imaging Society2019
Non-mono-exponential diffusion models for assessing early response of liver metastases to chemotherapy in colorectal Cancer.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 16 citations in OpenAlex.
- Apparent diffusion coefficient and kurtosis parameters show early response to anti-angiogenic therapy in patients with colorectal liver metastases.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Observational
- Nomograms Integrating MRI-derived Apparent Diffusion Coefficient and Clinicopathologic Features for Prediction of Axillary Lymph Node Metastasis in Breast Cancer.Radiology. Imaging cancer · 2025Article
- Predictive value of gemstone spectral imaging for chemotherapy response in colorectal cancer liver metastases: A retrospective study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- Application of advanced diffusion models from diffusion weighted imaging in a large cohort study of breast lesions.BMC medical imaging · 2023Article
- Role of advanced imaging techniques in the evaluation of oncological therapies in patients with colorectal liver metastases.World journal of gastroenterology · 2023Review
- 2450-MHz microwave ablation of liver metastases under 3.0 T wide-bore magnetic resonance guidance: a pilot study.Scientific reports · 2022Article
- Quantitative diffusion MRI of the abdomen and pelvis.Medical physics · 2022Article
- Diffusion-weighted MRI for predicting pathologic response to neoadjuvant chemotherapy in breast cancer: evaluation with mono-, bi-, and stretched-exponential models.Journal of translational medicine · 2021Article
- The value of DWI in predicting the response to synchronous radiochemotherapy for advanced cervical carcinoma: comparison among three mathematical models.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Observational
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8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPreoperative chemotherapy is becoming standard therapy for liver metastasis from colorectal cancer, so early assessment of treatment response is crucial to make a reasonable therapeutic regimen and avoid overtreatment, especially for patients with severe side effects. The role of three non-mono-exponential diffusion models, such as the kurtosis model, the stretched exponential model and the statistical model, were explored in this study to early assess the response to chemotherapy in patients with liver metastasis from colorectal cancer.
methodsThirty-three patients diagnosed as colorectal liver metastasis were evaluated in this study. Diffusion-weighted images with b values (0, 200, 500, 1000, 1500, 2000 s/mm
resultsSignificantly lower values of K (the kurtosis coefficient derived from the kurtosis model) and σ (the width of diffusion coefficient distribution in the statistical model) (P < 0.05) were observed in the respond group before treatment, as well as higher ΔK and Δσ values (P < 0.05) after the first cycle of chemotherapy were also found compared with the non-respond group. ROC analyses showed the K value acquired before treatment had the highest diagnostic performance (0.746) in distinguishing responders from non-responders. Furthermore, the high sensitivity (100%) and accuracy (76.3%) from the K value before treatment was found in assessing the response of colorectal liver metastasis to chemotherapy.
conclusionsThe non-mono-exponential diffusion models may be able to predict early response to chemotherapy in patients with colorectal liver metastasis.
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