Evidence map›Paper›PMID 31216773›Full record

ArticleInternational journal of molecular sciences2019

HNF4α and CDX2 Regulate Intestinal

Sylvester Larsen, Johanne Davidsen, Katja Dahlgaard, Ole B Pedersen, Jesper T Troelsen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sylvester LarsenDepartment of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark. sylvesterlarsen@outlook.com.
Johanne DavidsenDepartment of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark. johadav@ruc.dk.
Katja DahlgaardDepartment of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark. katja.d@hlgaard.dk.
Ole B PedersenDepartment of Clinical Immunology, Næstved Hospital, Ringstedgade 77B, 4700 Næstved, Denmark. olbp@regionsjaelland.dk.
Jesper T TroelsenDepartment of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark. troelsen@ruc.dk.
Roskilde University · DKNæstved Sygehus · DK

Funding

Independent Research Fund Denmark 4004-00140BRegion Zealand Foundation for Health and Research xxx
6 · The paper itself

Abstract

The Hippo pathway is important for tissue homeostasis, regulation of organ size andgrowth in most tissues. The co-transcription factor yes-associated protein 1 (YAP1) serves as a maindownstream effector of the Hippo pathway and its dysregulation increases cancer development andblocks colonic tissue repair. Nevertheless, little is known about the transcriptional regulation ofYAP1 in intestinal cells. The aim of this study to identify gene control regions in the

Indexed as

Gene Expression RegulationIntestinesPromoter Regions, GeneticAdaptor Proteins, Signal TransducingBase SequenceBinding SitesCDX2 Transcription FactorCell LineChromatinEnhancer Elements, GeneticHepatocyte Nuclear Factor 4HumansPhosphoproteinsProtein BindingTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCDX2 protein, humanCDX2 Transcription FactorChromatinHepatocyte Nuclear Factor 4HNF4A protein, humanPhosphoproteinsTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinscellular regulationgene regulationHippo pathwayintestinal epitheliumtranscriptional regulationtranscription factoryes‐associated protein 1 (YAP1)

Identifiers

PMID31216773
PMCPMC6627140
OpenAlexW2949086449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.