Evidence map›Paper›PMID 31216760›Full record

ArticleBiomolecules2019

COP9 Signalosome Interaction with UspA/Usp15 Deubiquitinase Controls VeA-Mediated Fungal Multicellular Development.

Cindy Meister, Karl G Thieme, Sabine Thieme, Anna M Köhler, Kerstin Schmitt, Oliver Valerius, Gerhard H Braus

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. ThemBio · 2026
    Article
  3. Article
  4. COP9 Signalosome's Role in Plant Defense Mechanisms.Plants (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Article
  7. Fungal COP9 signalosome assembly requires connection of two trimeric intermediates for integration of intrinsic deneddylase.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. The Multifaceted Roles of USP15 in Signal Transduction.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cindy MeisterDepartment of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. cmeiste@gwdg.de.
Karl G ThiemeDepartment of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. kthieme@gwdg.de.
Sabine ThiemeDepartment of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. sreen@gwdg.de.ORCID 0000-0002-0853-4723
Anna M KöhlerDepartment of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. akoehle3@gwdg.de.
Kerstin SchmittDepartment of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. kschmit1@gwdg.de.
Oliver ValeriusDepartment of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. ovaleri@gwdg.de.
Gerhard H BrausDepartment of Molecular Microbiology and Genetics and Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany. gbraus@gwdg.de.
University of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COP9 signalosome (CSN) and Den1/A deneddylases physically interact and promote multicellular development in fungi. CSN recognizes Skp1/cullin-1/Fbx E3 cullin-RING ligases (CRLs) without substrate and removes their posttranslational Nedd8 modification from the cullin scaffold. This results in CRL complex disassembly and allows Skp1 adaptor/Fbx receptor exchange for altered substrate specificity. We characterized the novel ubiquitin-specific protease UspA of the mold

Indexed as

Active Transport, Cell NucleusAspergillus nidulansCell NucleusCOP9 Signalosome ComplexFungal ProteinsProtein BindingTranscription, GeneticUbiquitin-Specific ProteasesCOP9 Signalosome ComplexFungal ProteinsUbiquitin-Specific ProteasesCOP9 signalosome (CSN), Aspergillus nidulansdeubiquitinationFbx23fungal developmentsecondary metabolismubiquitinubiquitin-specific proteaseUsp15/UspAvelvet domain proteins

Identifiers

PMID31216760
PMCPMC6627422
OpenAlexW2950598050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.