Evidence map›Paper›PMID 31216742›Full record

ArticleMolecules (Basel, Switzerland)2019

Heterologous Expression of Ilicicolin H Biosynthetic Gene Cluster and Production of a New Potent Antifungal Reagent, Ilicicolin J.

Xiaojing Lin, Siwen Yuan, Senhua Chen, Bin Chen, Hui Xu, Lan Liu, Huixian Li, Zhizeng Gao

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome Characteristics of the Endophytic FungusJournal of fungi (Basel, Switzerland) · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Journal of fungi (Basel, Switzerland) · 2021
    Article
  8. Article
  9. Article
  10. A Decade of Antifungal Leads from Natural Products: 2010-2019.Pharmaceuticals (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaojing LinSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. linxiaojing003@126.com.
Siwen YuanSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. swy1101@163.com.
Senhua ChenSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. chensenh@mail.sysu.edu.cn.
Bin ChenSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. chenbin25@mail.sysu.edu.cn.
Hui XuResearch Center of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. zyfxsherry@gzucm.edu.cn.
Lan LiuSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. cesllan@mail.sysu.edu.cn.ORCID 0000-0003-2765-4015
Huixian LiSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. lihx46@mail.sysu.edu.cn.
Zhizeng GaoSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China. gaozhizeng@mail.sysu.edu.cn.
Sun Yat-sen University · CNGuangzhou University of Chinese Medicine · CN

Funding

Basic Research Program of Sun Yat-Sen University Grant No. 17lgpy64National Natural Science Foundation of Guangdong No.2018A030313334Science and Technology Program of Guangzhou No.201804010476Special Fund for Economic Development of Guangdong Provence Marine Economic Development Grant NO. GDME-2018C004
6 · The paper itself

Abstract

Ilicicolin H is a broad-spectrum antifungal agent targeting mitochondrial cytochrome bc1 reductase. Unfortunately, ilicicolin H shows reduced activities in vivo. Here, we report our effort on the identification of ilicicolin H biosynthetic gene cluster (BGC) by genomic sequencing a producing strain,

Indexed as

Genes, FungalMultigene FamilyAntifungal AgentsAscomycotaBenzaldehydesBiosynthetic PathwaysChromatography, High Pressure LiquidGene Expression Regulation, FungalMolecular StructureAntifungal AgentsBenzaldehydesilicicolin Hbiosynthetic gene clusterheterologous productionilicicolin HNeonectria sp. DH2

Identifiers

PMID31216742
PMCPMC6631495
OpenAlexW2949998123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.