Evidence map›Paper›PMID 31216738›Full record

ReviewCells2019

Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?

Fabio Seiti Yamada Yoshikawa, Franciane Mouradian Emidio Teixeira, Maria Notomi Sato, Luanda Mara da Silva Oliveira

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
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  8. Article
  9. Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Fabio Seiti Yamada YoshikawaLaboratory of Dermatology and Immunodeficiencies, Department of Dermatology, Tropical Medical Institute, School of Medicine, University of São Paulo, 05403-000 São Paulo, Brazil. faseiti@gmail.com.ORCID 0000-0002-6112-7107
Franciane Mouradian Emidio TeixeiraLaboratory of Dermatology and Immunodeficiencies, Department of Dermatology, Tropical Medical Institute, School of Medicine, University of São Paulo, 05403-000 São Paulo, Brazil. franciane.mteixeira@usp.br.ORCID 0000-0001-5622-903X
Maria Notomi SatoLaboratory of Dermatology and Immunodeficiencies, Department of Dermatology, Tropical Medical Institute, School of Medicine, University of São Paulo, 05403-000 São Paulo, Brazil. marisato@usp.br.ORCID 0000-0002-7911-1824
Luanda Mara da Silva OliveiraLaboratory of Dermatology and Immunodeficiencies, Department of Dermatology, Tropical Medical Institute, School of Medicine, University of São Paulo, 05403-000 São Paulo, Brazil. luandaoliveira@usp.br.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are released by various cells and recently have attracted attention because they constitute a refined system of cell-cell communication. EVs deliver a diverse array of biomolecules including messenger RNAs (mRNAs), microRNAs (miRNAs), proteins and lipids, and they can be used as potential biomarkers in normal and pathological conditions. The cargo of EVs is a snapshot of the donor cell profile; thus, in viral infections, EVs produced by infected cells could be a central player in disease pathogenesis. In this context, miRNAs incorporated into EVs can affect the immune recognition of viruses and promote or restrict their replication in target cells. In this review, we provide an updated overview of the roles played by EV-delivered miRNAs in viral infections and discuss the potential consequences for the host response. The full understanding of the functions of EVs and miRNAs can turn into useful biomarkers for infection detection and monitoring and/or uncover potential therapeutic targets.

Indexed as

BiomarkersCell CommunicationExosomesExtracellular VesiclesHumansMicroRNAsRNA, MessengerVirus DiseasesBiomarkersMicroRNAsRNA, MessengerDNA virusextracellular vesiclesmiRNAsRNA virus

Identifiers

PMID31216738
PMCPMC6627707
OpenAlexW2952474297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.