ArticleLife (Basel, Switzerland)2019
Emergence of a "Cyclosome" in a Primitive Network Capable of Building "Infinite" Proteins.
Article in Life (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Traces of a Primitive RNA Ring in Current Genomes.Biology · 2025Article
- Information Gradient among Nucleotide Sequences of Essential RNAs from an Evolutionary Perspective.International journal of molecular sciences · 2024Article
- Primitive Oligomeric RNAs at the Origins of Life on Earth.International journal of molecular sciences · 2023Article
- Evolution of the genetic code.Transcription · 2021Review
- Origin of Life: The Point of No Return.Life (Basel, Switzerland) · 2020Article
- First arrived, first served: competition between codons for codon-amino acid stereochemical interactions determined early genetic code assignments.Die Naturwissenschaften · 2020Article
- Article
- Pentamers with Non-redundant Frames: Bias for Natural Circular Code Codons.Journal of molecular evolution · 2020Article
- The primordial tRNA acceptor stem code from theoretical minimal RNA ring clusters.BMC genetics · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We argue for the existence of an RNA sequence, called the AL (for ALpha) sequence, which may have played a role at the origin of life; this role entailed the AL sequence helping generate the first peptide assemblies via a primitive network. These peptide assemblies included "infinite" proteins. The AL sequence was constructed on an economy principle as the smallest RNA ring having one representative of each codon's synonymy class and capable of adopting a non-functional but nevertheless evolutionarily stable hairpin form that resisted denaturation due to environmental changes in pH, hydration, temperature, etc. Long subsequences from the AL ring resemble sequences from tRNAs and 5S rRNAs of numerous species like the proteobacterium,
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