ArticleThe American journal of clinical nutrition2019
Genetic overlap between executive functions and BMI in childhood.
Article in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes.Journal of translational medicine · 2025Article
- Distinct Constellations of Common Risk Factors Differentially Relate to Executive-Function Ability in Children.Psychological science · 2024Article
- Inhibitory control mediates the association between body mass index and math performance in children: A cross-sectional study.PloS one · 2024Article
- Children at high familial risk for obesity show executive functioning deficits prior to development of excess weight status.Obesity (Silver Spring, Md.) · 2023Article
- Article
- Anthropometric Parameters, Physical Activity, Physical Fitness, and Executive Functions among Primary School Children.International journal of environmental research and public health · 2022Article
- A novel model of obesity prediction: Neurobehaviors as targets for treatment.Behavioral neuroscience · 2021Article
- Abnormal body mass index may be related to poor social function of female children by a propensity score matching analysis.Scientific reports · 2021Article
- Executive function phenotypes in pediatric obesity.Pediatric obesity · 2020Article
- The orbitofrontal cortex, food intake and obesityJournal of psychiatry & neuroscience : JPN · 2020Review
- Associations between attention deficit hyperactivity disorder symptoms and eating behaviors in early childhood.Pediatric obesity · 2020Article
- Associations Between Physical Fitness and Brain Structure in Young Adulthood.Frontiers in psychology · 2020Article
- It's not all in your head: Genetic underpinnings of the relationship between executive function and BMI.The American journal of clinical nutrition · 2019Article
- Stability of Aging- and Cognition-Related Methylation Profile Scores Across Two Waves in Children and Adolescents.Child developmentArticle
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundExecutive functions (EFs) comprise a group of cognitive processes that selectively control and regulate attention. Inverse relations have been reported between EFs and BMI. However, the mechanisms underlying this association are not well understood.
objectivesWe aimed to decompose the inverse relation between EFs and BMI into genetic and environmental components.
methodsWe employed a cross-sectional analysis of data from 869 twins aged 7-15 y from the Texas Twin Project, who completed a neuropsychological test battery measuring 4 EFs (switching, inhibitory control, working memory, and updating); academic achievement (reading and mathematics); and general cognitive abilities (general intelligence/intelligence quotient; crystallized and fluid intelligence; and processing speed). Participants also had their height and weight measured.
resultsAfter controlling for age, sex, and race/ethnicity, BMI was inversely associated with a general EF factor representing the capacity to control and regulate goal-oriented behaviors (r = -0.125; P = 0.01; Q = 0.04). This inverse BMI-EF association was due to a significant overlap in genetic factors contributing to each phenotype (genetic correlation, rA, = -0.15; P < 0.001). Shared genetic influences accounted for 80% of the phenotypic association.
conclusionsChildren with higher general EF have lower BMIs, and this association is primarily attributable to shared genetic influences on both phenotypes. The results emphasize that higher weight associates not only with physical sequelae, but also with important cognitive attributes. This work adds to a growing body of research suggesting there are sets of genetic variants common across physical health and cognitive functioning.
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