ReviewPediatric research2021
Stimulating and maintaining spontaneous breathing during transition of preterm infants.
Review in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Initial CPAP of 5 versus 8 cmHEuropean journal of pediatrics · 2026Trial
- Non-invasive open lung strategy in delivery room: randomized controlled trial (OpenCPAP-DR).European journal of pediatrics · 2025Trial
- The Effect of Antenatal Paracetamol on Breathing Effort of Premature Infants at Birth: A Feasibility Trial.Children (Basel, Switzerland) · 2026Article
- Neonatal pulmonology: optimizing transition and lung function in preterm infants.Pediatric research · 2025Article
- Circulating prostaglandin EFrontiers in pediatrics · 2025Article
- The effect of histological and subclinical chorioamnionitis and funisitis on breathing effort in premature infants at birth: a retrospective cohort study.European journal of pediatrics · 2024Article
- The influence of chorioamnionitis on respiratory drive and spontaneous breathing of premature infants at birth: a narrative review.European journal of pediatrics · 2024Review
- Transferring an extremely premature infant to an extra-uterine life support system: a prospective view on the obstetric procedure.Frontiers in pediatrics · 2024Review
- From intra- to extra-uterine: early phase design of a transfer to extra-uterine life support through medical simulation.Frontiers in medical technology · 2024Article
- Variation in delivery room management of preterm infants across Europe: a survey of the Union of European Neonatal and Perinatal Societies.European journal of pediatrics · 2023Article
- Cardiac Asystole at Birth Re-Visited: Effects of Acute Hypovolemic Shock.Children (Basel, Switzerland) · 2023Review
- Low-Cost SpO2 Integrated Neonatal CPAP Device for Low Resource Setting.Medical devices (Auckland, N.Z.) · 2023Article
- Making the Argument for Intact Cord Resuscitation: A Case Report and Discussion.Children (Basel, Switzerland) · 2022Review
- Feasibility and Effect of Physiological-Based CPAP in Preterm Infants at Birth.Frontiers in pediatrics · 2021Article
- Ductal Flow Ratio as Measure of Transition in Preterm Infants After Birth: A Pilot Study.Frontiers in pediatrics · 2021Article
- [Newborn resuscitation and support of transition of infants at birth].Notfall & rettungsmedizin · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most preterm infants breathe at birth, but need additional respiratory support due to immaturity of the lung and respiratory control mechanisms. To avoid lung injury, the focus of respiratory support has shifted from invasive towards non-invasive ventilation. However, applying effective non-invasive ventilation is difficult due to mask leak and airway obstruction. The larynx has been overlooked as one of the causes for obstruction, preventing face mask ventilation from inflating the lung. The larynx remains mostly closed at birth, only opening briefly during a spontaneous breath. Stimulating and supporting spontaneous breathing could enhance the success of non-invasive ventilation by ensuring that the larynx remains open. Maintaining adequate spontaneous breathing and thereby reducing the need for invasive ventilation is not only important directly after birth, but also in the first hours after admission to the NICU. Respiratory distress syndrome is an important cause of respiratory failure. Traditionally, treatment of RDS required intubation and mechanical ventilation to administer exogenous surfactant. However, new ways have been implemented to administer surfactant and preserve spontaneous breathing while maintaining non-invasive support. In this narrative review we aim to describe interventions focused on stimulation and maintenance of spontaneous breathing of preterm infants in the first hours after birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.