ArticleCerebral cortex (New York, N.Y. : 1991)2021
In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Trial
- Alzheimer's disease and memantine effects on NMDA-receptor blockade: non-invasive in vivo insights from magnetoencephalography.Molecular psychiatry · 2026Article
- AI-driven magnetoencephalography biomarkers in dementia risk prediction: current evidence, challenges and future perspectives.Frontiers in dementia · 2026Review
- Neurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography.Human brain mapping · 2025Article
- Model-Based Approaches to Investigating Mismatch Responses in Schizophrenia.Clinical EEG and neuroscience · 2025Review
- Reliability of dynamic causal modelling of resting-state magnetoencephalography.Human brain mapping · 2024Article
- Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response.NeuroImage. Clinical · 2024Article
- The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials.Frontiers in aging neuroscience · 2024Article
- Neurophysiological consequences of synapse loss in progressive supranuclear palsy.Brain : a journal of neurology · 2023Article
- Changes in Visual Long-Term Potentiation Show Preserved Cyclicity in Human Females Taking Combined Oral Contraceptives.Neuroendocrinology · 2023Article
- The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.Translational psychiatry · 2022Article
- Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia.Biological psychiatry · 2022Article
- Evidence and implications of abnormal predictive coding in dementia.Brain : a journal of neurology · 2021Review
- Processing of Degraded Speech in Brain Disorders.Brain sciences · 2021Review
- Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex.PLoS computational biology · 2021Article
- Decoding expectation and surprise in dementia: the paradigm of music.Brain communications · 2021Article
- The human motor cortex microcircuit: insights for neurodegenerative disease.Nature reviews. Neuroscience · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The analysis of neural circuits can provide crucial insights into the mechanisms of neurodegeneration and dementias, and offer potential quantitative biological tools to assess novel therapeutics. Here we use behavioral variant frontotemporal dementia (bvFTD) as a model disease. We demonstrate that inversion of canonical microcircuit models to noninvasive human magnetoencephalography, using dynamic causal modeling, can identify the regional- and laminar-specificity of bvFTD pathophysiology, and their parameters can accurately differentiate patients from matched healthy controls. Using such models, we show that changes in local coupling in frontotemporal dementia underlie the failure to adequately establish sensory predictions, leading to altered prediction error responses in a cortical information-processing hierarchy. Using machine learning, this model-based approach provided greater case-control classification accuracy than conventional evoked cortical responses. We suggest that this approach provides an in vivo platform for testing mechanistic hypotheses about disease progression and pharmacotherapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.