ArticlePloS one2019
Inverse effects of tDCS over the left versus right DLPC on emotional processing: A pupillometry study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation.Scientific reports · 2021Trial
- Intertemporal meditation regulates time perception and emotions: an exploratory fNIRS study.Social cognitive and affective neuroscience · 2025Article
- Evidence of physiological changes associated with single-session pre-frontal tDCS: a pilot study.Frontiers in human neuroscience · 2025Article
- Globus pallidus externus correlates with arousal in disorders of consciousness: a resting-state functional MRI study.Frontiers in neuroscience · 2025Article
- A neurocognitive mechanism for increased cooperation during group formation.Communications psychology · 2024Article
- The neural structures of theory of mind are valence-sensitive: evidence from three tDCS studies.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Trait-related neural basis of attentional bias to emotions: a tDCS study.Cognitive, affective & behavioral neuroscience · 2023Article
- Mind the social feedback: effects of tDCS applied to the left DLPFC on psychophysiological responses during the anticipation and reception of social evaluations.Social cognitive and affective neuroscience · 2022Article
- Transcranial Direct Current Stimulation Over the Left Dorsolateral Prefrontal Cortex Reduced Attention Bias Toward Negative Facial Expression: A Pilot Study in Healthy Subjects.Frontiers in neuroscience · 2022Article
- Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination.Scientific reports · 2021Article
- The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions.Scientific reports · 2021Article
- Prefrontal tDCS Attenuates Self-Referential Attentional Deployment: A Mechanism Underlying Adaptive Emotional Reactivity to Social-Evaluative Threat.Frontiers in human neuroscience · 2021Article
- Prefrontal transcranial direct current stimulation over the right prefrontal cortex reduces proactive and reactive control performance towards emotional material in healthy individuals.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe Dorsolateral prefrontal cortex (DLPFC) is implicated in cognitive and emotional responses. Yet, research that investigates the causal role of the left versus right DLPFC during the processes of emotion appraisal is lacking. In the current study, transcranial direct current stimulation (tDCS) was used to disentangle the functional lateralization of the DLPFC on emotional processing in response to the anticipation of, and subsequent confrontation with emotional stimuli in healthy volunteers.
methodsForty-eight subjects received both active and sham (on separate days) anodal tDCS over either the left (N = 24) or right (N = 24) DLPFC. Subjects' pupil dilation (PD, a physiological marker of cognitive resource allocation) was recorded while performing an appraisal task in which negative and positive emotion eliciting images were presented, each preceded by an informative cue indicating the valence of the upcoming stimulus.
resultsAs compared to sham stimulation, left DLPFC anodal tDCS resulted in increased PD when confronted with negative emotional images, whereas right DLPFC anodal tDCS resulted in decreased PD when confronted with emotional images, irrespective of valence. LIMITATIONS: The interpretation of pupil dilation in response to emotional stimuli is limited.
conclusionThese findings suggest inverse lateralized DLPFC effects on cognitive resource allocation (as measured by pupillary responses) when confronted with emotional stimuli. The current findings may shed some light on mechanisms that explain the antidepressant effects of non-invasive brain stimulation of the left DLPFC.
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