ArticlePloS one2019
Conditioned taste aversion versus avoidance: A re-examination of the separate processes hypothesis.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal.Nutrients · 2023Trial
- Sex differences in oscillatory signaling dynamics in the prelimbic cortex and nucleus accumbens core during negative affect.Behavioural brain research · 2025Article
- The antiemetic actions of GIP receptor agonism.American journal of physiology. Endocrinology and metabolism · 2024Review
- Evaluating the Presence of Disgust in Animals.Animals : an open access journal from MDPI · 2024Review
- Evaluating proxies for motion sickness in rodent.IBRO neuroscience reports · 2023Article
- Food Restriction in Anorexia Nervosa in the Light of Modern Learning Theory: A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2023Review
- Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences.Science advances · 2023Article
- Oromotor and somatic taste reactivity during sucrose meals reveals internal state and stimulus palatability after gastric bypass in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Early Postoperative Exposure to High-Fat Diet Does Not Increase Long-Term Weight Loss or Fat Avoidance After Roux-en-Y Gastric Bypass in Rats.Frontiers in nutrition · 2022Article
- Impact of the Aversive Effects of Drugs on Their Use and Abuse.Behavioural neurology · 2022Review
- Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Hormones and behavior · 2021Article
- Meal Patterns and Food Choices of Female Rats Fed a Cafeteria-Style Diet Are Altered by Gastric Bypass Surgery.Nutrients · 2021Article
- Features of behavioral changes underlying conditioned taste aversion in the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.Cell reports · 2020Article
- Parabrachial Complex: A Hub for Pain and Aversion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Rats not only avoid ingesting a substance associated with LiCl toxicosis, but they display rejection reflexes (e.g., gapes) to its taste; this latter response is thought to reflect disgust or taste aversion. Prior work has shown that rats also avoid consuming foods/fluids associated with other adverse gastrointestinal (GI) effects like lactose indigestion but without the concomitant change in oromotor responses (taste reactivity; TR) indicative of aversion. Because of interpretive limitations of the methods used in those studies, we revisited the taste aversion-avoidance distinction with a design that minimized non-treatment differences among groups. Effects on intake and preference (Experiments 1a, 1b, and 2), as well as consummatory (TR, Experiment 1a and 1b) and appetitive (Progressive Ratio, Experiment 2) behaviors to the taste stimulus were assessed after training. In both experiments, rats were trained to associate 0.2% saccharin (CS) with intraduodenal infusions of LiCl, Lactose, or NaCl control. Rats trained with 18% lactose, 0.3 and 1.5 mEq/kg dose of LiCl subsequently avoided the taste CS in post-training single-bottle intake tests and two-bottle choice tests. However, only those trained with 1.5 mEq/kg LiCl displayed post-conditioning increases in taste CS-elicited aversive TR (Experiment 1a and 1b). This dose of LiCl also led to reductions in breakpoint for saccharin. The fact that conditioned avoidance is not always accompanied by changes in other common appetitive and/or consummatory indices of ingestive motivation further supports a functional dissociation between these processes, and highlights the intricacies of visceral influences on taste-guided ingestive motivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.