Evidence map›Paper›PMID 31216194›Full record

ArticleAmerican journal of physiology. Cell physiology2019

The Bardet-Biedl syndrome protein complex regulates cell migration and tissue repair through a Cullin-3/RhoA pathway.

Deng-Fu Guo, Kamal Rahmouni

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. T cell-specific deficiency in BBSome component BBS1 interferes with selective immune responses.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. KCells · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Deng-Fu GuoDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Kamal RahmouniDepartment of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa.ORCID 0000-0001-5136-6748
University of Iowa · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
Request for Funds to Purchase a Replacement Laser Scanning Confocal MicroscopeS10RR025439 · NCRR · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2009 to 2009
$500k
Neuronal Mechanisms of Obesity-Induced HypertensionI01BX004249 · VA · IOWA CITY VA MEDICAL CENTER · PI KAMAL RAHMOUNI · 2019 to 2026
–
BLRD VA I01 BX004249NCRR NIH HHS S10 RR025439NHLBI NIH HHS P01 HL084207
6 · The paper itself

Abstract

Cell motility and migration play critical roles in various physiological processes and disease states. Here, we show that the BBBsome, a macromolecule composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1, is a critical determinant of cell migration and wound healing. Fibroblast cells derived from mice or humans harboring a homozygous missense mutation (BBS1

Indexed as

Bardet-Biedl SyndromeAnimalsCell MovementCells, CulturedCullin ProteinsCyclopentanesEnzyme InhibitorsFemaleGene Knock-In TechniquesHumansMaleMiceMice, Inbred C57BLMice, TransgenicMicrotubule-Associated ProteinsPyrimidinesBbs1 protein, humanCul3 protein, mouseCullin ProteinsCyclopentanesEnzyme InhibitorsMicrotubule-Associated ProteinspevonedistatPyrimidinesrhoA GTP-Binding ProteinRhoA protein, mouseBadet-Biedl syndrome proteinscell motilityciliawound healing

Identifiers

PMID31216194
PMCPMC6766617
OpenAlexW2953354010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.