ArticleAngewandte Chemie (International ed. in English)2019
Dendrimer Conjugation Enables Multiphoton Chemical Neurophysiology Studies with an Extended π-Electron Caging Chromophore.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- From Structure to Function: The Promise of PAMAM Dendrimers in Biomedical Applications.Pharmaceutics · 2025Review
- Review
- Two-Photon Absorbing Dendrimers and Their Properties-An Overview.International journal of molecular sciences · 2024Review
- Reverse Engineering Caged Compounds: Design Principles for their Application in Biology.Angewandte Chemie (International ed. in English) · 2023Review
- The yin and yang of intracellular delivery of amphipathic optical probes usingChemical communications (Cambridge, England) · 2022Article
- Selective Modification for Red-Shifted Excitability: A Small Change in Structure, a Huge Change in Photochemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.Chemical reviews · 2020Article
- Useful Caged Compounds for Cell Physiology.Accounts of chemical research · 2020Article
- Cloaked caged glutamate eliminates off-target GABA-A receptor antagonism and opens a new door in neuroscience.Lab animal · 2020Article
- Long-wavelength photoremovable protecting groups: On the way toComputational and structural biotechnology journal · 2020Review
- Photopotentiation of the GABAProceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have developed a caged neurotransmitter using an extended π-electron chromophore for efficient multiphoton uncaging on living neurons. Widely studied in a chemical context, such chromophores are inherently bioincompatible due to their highly lipophilic character. Attachment of two polycarboxylate dendrimers, a method we call "cloaking", to a bisstyrylthiophene (or BIST) core effectively transformed the chromophore into a water-soluble optical probe, whilst maintaining the high two-photon absorption of over 500 GM. Importantly, the cloaked caged compound was biologically inert at the high concentrations required for multiphoton chemical physiology. Thus, in contrast to non-cloaked BIST compounds, the BIST-caged neurotransmitter can be safely delivered onto neurons in acutely isolated brain slices, thereby enabling high-resolution two-photon uncaging without any side effects. We expect that our cloaking method will enable the development of new classes of cell-compatible photolabile probes using a wide variety of extended π-electron caging chromophores.
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Registered trials
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