Evidence map›Paper›PMID 31216094›Full record

ArticleMaternal & child nutrition2020

Development of a biochemical marker to detect current breast milk intake.

Ruth Addison, Lauren Hill, Lars Bode, Bianca Robertson, Biswa Choudhury, David Young, Charlotte Wright, Clare Relton, Ada L Garcia, David M Tappin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal & child nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Ruth AddisonNHS Ayrshire & Arran Primary Care Trust, Rainbow House Paediatric Unit, Ayrshire Central Hospital, Irvine, UK.
Lauren HillGeneral Paediatrics, Pinderfields General Hospital, Wakefield, UK.ORCID 0000-0001-9444-4435
Lars BodeDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (LRF MOMI CORE), University of California, San Diego, California.ORCID 0000-0002-9914-9571
Bianca RobertsonDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (LRF MOMI CORE), University of California, San Diego, California.
Biswa ChoudhuryGlycoanalytical Core, Glycobiology Research and Training Center, University of California, San Diego, California.
David YoungDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, UK.
Charlotte WrightSection of Child Health, School of Medicine, Glasgow University, Glasgow, UK.ORCID 0000-0001-6256-6315
Clare ReltonScHARR, University of Sheffield, Sheffield, UK.ORCID 0000-0001-8530-5011
Ada L GarciaHuman Nutrition, School of Medicine, Dentistry and Nursing, Glasgow University, Glasgow, UK.ORCID 0000-0002-3526-2380
David M TappinSection of Child Health, School of Medicine, Glasgow University, Glasgow, UK.ORCID 0000-0001-8914-055X
University of Glasgow · GBMothers’ Milk Bank · USNHS Ayrshire and Arran · GBPinderfields Hospital · GBQueen Mary University of London · GBUniversity of California San Diego · USUniversity of Strathclyde · GB

Funding

Medical Research Council MR/J000434/1
6 · The paper itself

Abstract

The WHO recommends exclusive breastfeeding for 6 months, but despite interventions, breastfeeding rates remain stubbornly low. Financial voucher incentives have shown promise but require a biomarker for validation of intake. This study aimed to develop a simple biochemical assay of infant urine that would tell if an infant was receiving any breast milk to validate maternal report. Urine samples were collected and snap frozen from 34 infants attending with minor illness or feeding problems, of whom 12 infants were exclusively breastfed, nine exclusively formula fed, and 11 mixed breast/formula fed. High-performance anion exchange chromatography was used to identify discriminating patterns of monosaccharide composition of unconjugated glycans in a sequence of three experiments. The absolute concentration of all human milk oligosaccharides measured blind could detect "any breastfeeding" only with a sensitivity of 48% and specificity of 78%. Unblinded examination of N-acetylglucosamine (GlcNAc) measured as GlcNH

Indexed as

Breast FeedingAcetylglucosamineAdultBiomarkersChromatography, High Pressure LiquidFemaleHumansInfantInfant, NewbornMannoseMilk, HumanMonosaccharidesOligosaccharidesSensitivity and SpecificityAcetylglucosamineBiomarkersMannoseMonosaccharidesOligosaccharidesbreastfeedingcarbohydrate biochemistryhealth promotionmilk humanoligosaccharidesprogramme evaluation

Identifiers

PMID31216094
PMCPMC7038895
OpenAlexW2952234511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.