Evidence map›Paper›PMID 31216050›Full record

Trial reportClinical and experimental immunology2019

T cell functionality in HIV-1, HIV-2 and dually infected individuals: correlates of disease progression and immune restoration.

S Salwe, V Padwal, V Nagar, P Patil, V Patel

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Clinical and experimental immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

S SalweDepartment of Biochemistry and Virology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai, India.
V PadwalDepartment of Biochemistry and Virology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai, India.
V NagarDepartment of Medicine, Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, India.
P PatilDepartment of Medicine, Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, India.
V PatelDepartment of Biochemistry and Virology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai, India.ORCID 0000-0001-6661-3238
National Institute for Research in Reproductive Health · INGrant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of suppressive anti-retroviral therapy (ART) in eliciting restoration of dysregulated immune function remains unclear in HIV-1 infection. Also, due to tailoring of therapeutic regimens towards HIV-1, this possible impairment of therapy may be even more pronounced in HIV-2 and dual (HIV-D) infection. Thus, we evaluated the impact of ART on immune restoration by assessing T cell functions, including HIV specific responses in HIV-1-, HIV-2- and HIV-D-infected individuals. Both ART-treated and naive infected subjects showed persistently altered frequency of CD4

Indexed as

Immunologic MemoryAdultDisease ProgressionFemaleHIV-1HIV-2HIV InfectionsHumansInterferon-gammaInterleukin-2MaleMiddle AgedRecovery of FunctionTh17 CellsT-Lymphocytes, RegulatoryIFNG protein, humanIL2 protein, humanInterferon-gammaInterleukin-2anti-retroviral therapydisease progressiondual (HIV-D) infectionHIV-2 infectionHIV-specific responsesimmune restoration

Identifiers

PMID31216050
PMCPMC6797902
OpenAlexW2950289579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.