ArticleNucleic acids research2019
Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF.
Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- A dual-host regulatory hub integrating biofilm formation and innate immunity resistance.Nature communications · 2026Article
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- A population model reveals a surprising role of stochastic cell division in epigenetic memory systems.iScience · 2025Article
- Identification and Characterization of a New Regulator, TagR, for Environmental Stress Resistance Based on the DNA Methylome of Streptomyces roseosporus.Microbiology spectrum · 2023Article
- Roles of adenine methylation in the physiology of Lacticaseibacillus paracasei.Nature communications · 2023Article
- Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria.Frontiers in microbiology · 2023Review
- Analysis ofFrontiers in cellular and infection microbiology · 2023Review
- Identifying Bacterial Lineages in Salmonella by Flow Cytometry.EcoSal Plus · 2022Review
- Bacterial Transcription Factors Bind to Coding Regions and Regulate Internal Cryptic Promoters.mBio · 2022Article
- Roles of adenine methylation and genetic mutations in adaptation to different temperatures inEpigenetics · 2022Article
- Integration of themBio · 2022Article
- Novel Identification of Bacterial Epigenetic Regulations Would Benefit From a Better Exploitation of Methylomic Data.Frontiers in microbiology · 2021Review
- Contribution of DNA adenine methylation to gene expression heterogeneity in Salmonella enterica.Nucleic acids research · 2020Article
- Recent Advances in Our Understanding of the Diversity and Roles of Chaperone-Usher Fimbriae in FacilitatingFrontiers in cellular and infection microbiology · 2020Review
- The bacterial epigenome.Nature reviews. Microbiology · 2020Review
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5 authors.
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Abstract
Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself. StdE activates transcription of the hdfR gene, and StdF activates std transcription together with HdfR. Binding of HdfR upstream of the std promoter is hindered by methylation of GATC sites located within the upstream activating sequence (UAS). Epigenetic control by Dam methylation thus antagonizes formation of the StdE-StdF-HdfR loop and tilts the std switch toward the StdOFF state. In turn, HdfR binding hinders methylation of the UAS, permitting activation of the StdE-StdF-HdfR loop and concomitant formation of StdON cells. Bistability is thus the outcome of competition between DNA adenine methylation and the StdE-StdF-HdfR activator loop.
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