ArticleJournal of psychopharmacology (Oxford, England)2019
Orbitofrontal cortex volume prospectively predicts cannabis and other substance use onset in adolescents.
Article in Journal of psychopharmacology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- The Influence of Cannabis and Nicotine Co-use on Neuromaturation: A Systematic Review of Adolescent and Young Adult Studies.Biological psychiatry · 2021Pooled it
- Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders.Molecular psychiatry · 2026Article
- Age of onset of nicotine use and severity of nicotine addiction symptoms are associated with hippocampal volume in late adolescents and emerging adults.Frontiers in adolescent medicine · 2025Article
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Adolescent Neurodevelopment Within the Context of Impulsivity and Substance Use.Current addiction reports · 2023Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Diminished Structural Brain Integrity in Long-term Cannabis Users Reflects a History of Polysubstance Use.Biological psychiatry · 2022Article
- What do neuroanatomical networks reveal about the ontology of human cognitive abilities?iScience · 2022Article
- Associations between adolescent cannabis use and young-adult functioning in three longitudinal twin studies.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Promising vulnerability markers of substance use and misuse: A review of human neurobehavioral studies.Neuropharmacology · 2021Review
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Cannabis and the developing brain: What does the evidence say?Birth defects research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundIdentifying neural characteristics that predict cannabis initiation is important for prevention efforts. The orbitofrontal cortex is critical for reward response and may be vulnerable to substance-induced alterations.
aimsWe measured orbitofrontal cortex thickness, surface area, and volume prior to the onset of use to predict cannabis involvement during an average nine-year follow-up.
methodsAdolescents (
resultsLarger left lateral orbitofrontal cortex volume predicted classification as cannabis user by follow-up (
conclusionsLarger left lateral orbitofrontal cortex measured from ages 12-15 years and prior to initiation of substance use was related to greater reward responsiveness at baseline and predicted classification as a cannabis user and cannabis+alcohol co-user by final follow-up. Larger lateral orbitofrontal cortex volume may represent aberrant orbitofrontal cortex maturation and increasing vulnerability for later substance use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.