Evidence map›Paper›PMID 31215802›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex.

Karl A Nath, Vesna D Garovic, Joseph P Grande, Anthony J Croatt, Allan W Ackerman, Gianrico Farrugia, Zvonimir S Katusic, John D Belcher, Gregory M Vercellotti

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Rodent models of AKI and AKI-CKD transition: an update in 2024.American journal of physiology. Renal physiology · 2024
    Review
  2. Review
  3. The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications.Biochimica et biophysica acta. Molecular basis of disease · 2022
    Article
  4. Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases.International journal of molecular sciences · 2021
    Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Karl A NathDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Vesna D GarovicDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Joseph P GrandeDepartment of Pathology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5674-1682
Anthony J CroattDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Allan W AckermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Gianrico FarrugiaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-3473-5235
Zvonimir S KatusicDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
John D BelcherDivision of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.
Gregory M VercellottiDivision of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.
Mayo Clinic · USUniversity of Minnesota · US

Funding

Physiological Characterization and Data Integration CoreP01DK068055 · NIDDK · MAYO CLINIC ROCHESTER · PI BHARUCHA, ADIL E. · 2004 to 2019
$23.8M
HBI-002 to Prevent Vaso-Occlusive Crises in Sickle Cell DiseaseR44HL131065 · NHLBI · HILLHURST BIOPHARMACEUTICALS, INC. · PI GOMPERTS, EDWARD · 2018 to 2025
$5.0M
Heme toxicity and vaso-occlusion in sickle cell diseaseR01HL114567 · NHLBI · UNIVERSITY OF MINNESOTA · PI VERCELLOTTI, GREGORY M · 2012 to 2020
$4.4M
Hypertensive pregnancy disorders and future coronary artery diseaseR01HL136348 · NHLBI · MAYO CLINIC ROCHESTER · PI GAROVIC, VESNA D · 2018 to 2022
$2.6M
RENAL INJURY AND ADAPTATION TO HEME PROTEINSR01DK047060 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NATH, KARL A. · 1993 to 2018
$2.2M
Oral Carbon Monoxide Therapeutic to Prevent Vaso-Occlusive Crises in Sickle Cell DiseaseR43HL131065 · NHLBI · HILLHURST BIOPHARMACEUTICALS, INC. · PI BELCHER, JOHN D, GOMPERTS, EDWARD · 2016 to 2017
$300k
NHLBI NIH HHS R01 HL114567NHLBI NIH HHS R01 HL136348NHLBI NIH HHS R43 HL131065NHLBI NIH HHS R44 HL131065NIDDK NIH HHS P01 DK068055NIDDK NIH HHS R01 DK047060
6 · The paper itself

Abstract

Heme oxygenase (HO) activity is exhibited by inducible (HO-1) and constitutive (HO-2) proteins. HO-1 protects against ischemic and nephrotoxic acute kidney injury (AKI). We have previously demonstrated that HO-2 protects against heme protein-induced AKI. The present study examined whether HO-2 is protective in ischemic AKI. Renal ischemia was imposed on young and aged HO-2

Indexed as

Acute Kidney InjuryAge FactorsAnimalsDisease Models, AnimalFemaleHeme Oxygenase (Decyclizing)KidneyMaleMice, KnockoutPhosphorylationReperfusion InjurySex FactorsSignal TransductionSTAT3 Transcription Factorheme oxygenase-2Heme Oxygenase (Decyclizing)Stat3 protein, mouseSTAT3 Transcription Factoracute kidney injuryagebiology of sex differencesheme oxygenase-2phospho-STAT3

Identifiers

PMID31215802
PMCPMC6842883
OpenAlexW2949731507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.