Evidence map›Paper›PMID 31215789›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis.

Debora I Sinner, Brenna Carey, Daniela Zgherea, K M Kaufman, Lauren Leesman, Robert E Wood, Michael J Rutter, Alessandro de Alarcon, Ravindhra G Elluru, John B Harley and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  15. BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  16. Article
  17. Development pattern of tracheal cartilage in human embryos.Clinical anatomy (New York, N.Y.) · 2021
    Article
  18. Article
  19. Article
  20. Hedgehog and WNT Signaling Hubs in Tracheal Morphogenesis.American journal of respiratory and critical care medicine · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Debora I SinnerDivision of Neonatology.ORCID 0000-0002-0704-5223
Brenna CareyTranslational Pulmonary Science Center.
Daniela ZghereaDivision of Pulmonary Medicine.
K M KaufmanCenter for Autoimmune Genomics and Etiology, and.
Lauren LeesmanDivision of Neonatology.
Robert E WoodDivision of Pulmonary Medicine.
Michael J RutterDivision of Ear Nose and Throat Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Alessandro de AlarconDivision of Ear Nose and Throat Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Ravindhra G ElluruDivision of Ear Nose and Throat Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
John B HarleyCenter for Autoimmune Genomics and Etiology, and.
Jeffrey A WhitsettDivision of Neonatology.
Bruce C TrapnellDivision of Neonatology.ORCID 0000-0003-2817-6254
Pulmonary Associates · USCincinnati Children's Hospital Medical Center · USUnited States Department of Veterans Affairs · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Pilot and Feasibility ProgramP30DK117467 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, MICHAEL A. HELMRATH · 2018 to 2026
$11.4M
Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3M
Role of GM-CSF in Myeloid Cell Function and Innate ImmunityR01HL085453 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C · 2007 to 2023
$6.5M
Pulmonary Macrophage Transplantation for Pulmonary Alveolar ProteinosisR01HL118342 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C, TRAPNELL, BRUCE COLSTON · 2014 to 2021
$4.5M
"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
RLDC: Molecular Pathway-Driven Diagnostics & Therapeutics for Rare Lung DiseasesU54HL127672 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C · 2014 to 2018
$3.7M
Molecular mechanisms underlying trachea formation and the pathology of tracheomalacia and complete tracheal ringsR01HL144774 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SINNER, DEBORA · 2019 to 2023
$2.2M
Molecular basis of dorsal-ventral patterning of the conducting airwaysR03HL133420 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SINNER, DEBORA · 2016 to 2017
$156k
NCATS NIH HHS UL1 TR001425NHLBI NIH HHS R01 HL085453NHLBI NIH HHS R01 HL118342NHLBI NIH HHS R01 HL144774NHLBI NIH HHS R03 HL133420NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01 HL134745NHLBI NIH HHS U54 HL127672NIDDK NIH HHS P30 DK117467
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCohort StudiesDisease Models, AnimalHumansMiceMutationRespiratory System AbnormalitiesTracheacartilageexome sequencingtrachealis muscletracheal ringstracheomalacia

Identifiers

PMID31215789
PMCPMC6857493
OpenAlexW2951567631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.