ArticleNeuromodulation : journal of the International Neuromodulation Society2020
Evoked Potentials Recorded From the Spinal Cord During Neurostimulation for Pain: A Computational Modeling Study.
Article in Neuromodulation : journal of the International Neuromodulation Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Postural changes and motor evoked potentials following percutaneous spinal cord epidural stimulation in spinal cord injury.Spinal cord series and cases · 2026Trial
- Molecular and Cellular Mechanisms of Spinal Cord Stimulation: Linking Dorsal Horn Circuits, Glia, and ECAP-Guided Therapy.International journal of molecular sciences · 2026Review
- History of SCS and patient-focused innovations: a manufacturer's perspective on the role of technology.Pain medicine (Malden, Mass.) · 2026Review
- Directional leads applied to spinal cord stimulation: A computational modelling study.PloS one · 2026Article
- Computational Optimization of Spinal Cord Stimulation for Dorsal Horn Interneuron Polarization.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Role of frequency-dependent and capacitive tissue properties in spinal cord stimulation models.Journal of neural engineering · 2025Article
- Closed-Loop Spinal Cord Stimulation in Chronic Pain Management: Mechanisms, Clinical Evidence, and Emerging Perspectives.Biomedicines · 2025Review
- Case report: Potential physiological sources of the late response in epidural spinal recordings induced by spinal cord stimulation during intraoperative neuromonitoring.Clinical neurophysiology practice · 2025Article
- Correlating Evoked Electromyography and Anatomic Factors During Spinal Cord Stimulation Implantation With Short-Term Outcomes.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- The role of spinal cord neuroanatomy and the variances of epidurally evoked spinal responses.Bioelectronic medicine · 2024Article
- Biophysics of Frequency-Dependent Variation in Paresthesia and Pain Relief during Spinal Cord Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Computational models of compound nerve action potentials: Efficient filter-based methods to quantify effects of tissue conductivities, conduction distance, and nerve fiber parameters.PLoS computational biology · 2024Article
- An optimization framework for targeted spinal cord stimulation.Journal of neural engineering · 2023Article
- Spatiotemporal Distribution of Electrically Evoked Spinal Compound Action Potentials During Spinal Cord Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Article
- Characterization and applications of evoked responses during epidural electrical stimulation.Bioelectronic medicine · 2023Article
- Methods and system for recording human physiological signals from implantable leads during spinal cord stimulation.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Neural Recruitment During Conventional, Burst, and 10-kHz Spinal Cord Stimulation for Pain.The journal of pain · 2022Article
- Exploration of the Supraspinal Hypotheses about Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation: A Systematic Review.Journal of clinical medicine · 2021Review
- [Simulation study of spinal cord stimulation evoked compound action potential].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesSpinal cord stimulation (SCS) for pain is typically implemented in an open-loop manner using parameters that remain largely unchanged. To improve the overall efficacy and consistency of SCS, one closed-loop approach proposes to use evoked compound action potentials (ECAPs) recorded from the SCS lead(s) as a feedback control signal to guide parameter selection. The goal of this study was to use a computational modeling approach to investigate the source of these ECAP recordings and technical and physiological factors that affect their composition.
methodsWe developed a computational model that coupled a finite element model of lower thoracic SCS with multicompartment models of sensory axons within the spinal cord. We used a reciprocity-based approach to calculate SCS-induced ECAPs recorded from the SCS lead.
resultsOur model ECAPs contained a triphasic, P1, N1, P2 morphology. The model P2-N1 amplitudes and conduction velocities agreed with previous experimental data from human subjects. Model results suggested that the ECAPs are dominated by the activation of axons with diameters 8.7-10.0 μm located in the dorsal aspect of the spinal cord. We also observed changes in the ECAP amplitude and shape due to the electrode location relative to the vertebrae and spinal cord.
conclusionOur modeling results suggest that clinically effective SCS relies on the activation of numerous axons within a narrow fiber diameter range and that several factors affect the composition of the ECAP recordings. These results can improve how we interpret and implement these recordings in a potential closed-loop approach to SCS.
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