ArticleThe Journal of physiology2019
Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts.
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Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart.iScience · 2026Article
- Clinically Relevant Doses of Remimazolam Modulate Cardiac Electrophysiology: Late Repolarization Prolongation and Increased Conduction Dispersion With Preserved QTc.Cardiology research and practice · 2026Article
- Molecular and cellular neurocardiology in heart disease.The Journal of physiology · 2025Review
- Impact of sympathetic nervous system on immune evasion in high-grade serous ovarian cancer: a review.Frontiers in oncology · 2025Review
- Sympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart.American journal of physiology. Heart and circulatory physiology · 2024Article
- Stronger stimulus triggers synaptic transmission faster through earlier started action potential.Cell communication and signaling : CCS · 2024Article
- The promise of cardiac neuromodulation: can computational modelling bridge the gap?The Journal of physiology · 2023Article
- A multiscale predictive digital twin for neurocardiac modulation.The Journal of physiology · 2023Article
- Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics.Science advances · 2023Article
- Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022Review
- High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones.JCI insight · 2022Article
- Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond.Frontiers in physiology · 2022Review
- Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications.Science advances · 2021Article
- L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes.The Journal of general physiology · 2021Article
- We are the change we seek.American journal of physiology. Heart and circulatory physiology · 2021Article
- Transcriptomic uniqueness and commonality of the ion channels and transporters in the four heart chambers.Scientific reports · 2021Article
- Adrenergic supersensitivity and impaired neural control of cardiac electrophysiology following regional cardiac sympathetic nerve loss.Scientific reports · 2020Article
- Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling.Journal of molecular and cellular cardiology · 2020Article
- Cardiac sympathetic nerve transdifferentiation reduces action potential heterogeneity after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Lianguo WangDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.ORCID 0000-0002-4747-0419
Stefano MorottiDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.ORCID 0000-0001-8679-665X
Srinivas TapaDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.
Samantha D Francis StuartDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.
Yanyan JiangDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.
Zhen WangDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.
Rachel C MylesInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0003-4670-361X
Kieran E BrackDepartment of Cardiovascular Sciences, University of Leicester, NIHR Leicester Biomedical Research Centre, Leicester, UK.
G André NgDepartment of Cardiovascular Sciences, University of Leicester, NIHR Leicester Biomedical Research Centre, Leicester, UK.
Donald M BersDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.ORCID 0000-0002-2237-9483
Eleonora GrandiDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.ORCID 0000-0002-4401-8857
Crystal M RipplingerDepartment of Pharmacology, School of Medicine, University of California, Davis, USA.ORCID 0000-0002-9908-4106
University of California, Davis · USUniversity of Leicester · GBUniversity of Glasgow · GB
Funding
Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4MUC Davis Biology ProgramR25GM056765 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI GOMES, ALDRIN V. · 1998 to 2019
$9.7MThe Role of Adrenergic Stimulation in ArrhythmogenesisR01HL111600 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal May Ripplinger · 2012 to 2026
$7.1MDevelopment of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7MIn silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7MSex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0MFunctional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8MIONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8MPredoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2MAKAP-dependent regulation of Cardiac SR Ca handlingR01HL133832 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2017 to 2020
$2.0MModeling of subcellular signaling crosstalk in failing myocytesR00HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2020 to 2022
$722kModeling of subcellular signaling crosstalk in failing myocytesK99HL138160 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOROTTI, STEFANO · 2018 to 2019
$237kBritish Heart Foundation RG/17/3/32774NHLBI NIH HHS K99 HL138160NHLBI NIH HHS R00 HL138160NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL111600NHLBI NIH HHS R01 HL128537NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL133832NHLBI NIH HHS R01 HL141214NIGMS NIH HHS R25 GM056765NIGMS NIH HHS T32 GM099608NIH HHS OT2 OD023848NIH HHS OT2 OD026580
Abstract
key pointsCardiac electrophysiology and Ca ABSTRACT: Sympathetic activation of the heart results in positive chronotropy and inotropy, which together rapidly increase cardiac output. The precise mechanisms that produce the electrophysiological and Ca
Indexed as
Action PotentialsHeart RateModels, CardiovascularStress, PhysiologicalAnimalsCalcium SignalingHeartMaleMiceMice, Inbred C57BLMyocardial ContractionRabbitsSympathetic Nervous Systemaction potentialintracellular Ca2+mathematical modellingOptical mappingsympathetic activation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.