ArticleBMC pregnancy and childbirth2019
Inappropriate use of ritodrine hydrochloride for threatened preterm birth in Japan: a retrospective cohort study using a national inpatient database.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Facility-Level Factors Associating Antenatal Corticosteroid Administration Rates and Subsequent Term Birth Rates: A Nationwide Cross-Sectional Observational Study Using the 2020-2022 Perinatal Registry Database in Japan.The journal of obstetrics and gynaecology research · 2026Observational
- Association between betamimetics tocolysis duration and maternal adverse events: a national real-world data analysis from Japan.Scientific reports · 2026Observational
- Article
- Threatened preterm labor in Japan: an evidence-practice gap in diagnosis, tocolysis, and guideline implementation.Frontiers in reproductive health · 2026Review
- Relationship between volatile anesthetics and functional outcomes in patients with subarachnoid hemorrhage.Journal of anesthesia, analgesia and critical care · 2025Article
- Prolonged administration of ritodrine hydrochloride in women with premature labor or threatened premature delivery based on empirical data in Japan.Scientific reports · 2025Article
- Trends and outcomes of chemotherapy timing in critically ill patients with hematologic malignancies using a Japanese national database.Scientific reports · 2025Article
- Association Between Atopic Dermatitis in Pregnant Women and Preterm Births: The Japan Environment and Children's Study.Maternal and child health journal · 2024Article
- Intrauterine Inflammation, Excessive Fetal Growth and Respiratory Morbidities in Moderate-To-Late Preterm Neonates.Neonatology · 2024Observational
- Comparison of the efficacy of phloroglucinol versus ritodrine hydrochloride in preventing miscarriage and adverse reactions.American journal of translational research · 2024Article
- Ritodrine-induced rhabdomyolysis and psychiatric symptoms: a case report and literature review.BMC pregnancy and childbirth · 2023Review
- Betamethasone use and risk factors for pulmonary edema during the perinatal period: a single-center retrospective cohort study in Japan.BMC pregnancy and childbirth · 2022Article
- Associations ofPharmaceutics · 2022Article
- Fetal biometric and Doppler measurements following abdominal radical trachelectomy in the second trimester of the pregnancy.BMC pregnancy and childbirth · 2022Article
- Tocolytic Treatment for the Prevention of Preterm Birth from a Taiwanese Perspective: A Survey of Taiwanese Obstetric Specialists.International journal of environmental research and public health · 2022Article
- Development and validation of a transcriptomic signature-based model as the predictive, preventive, and personalized medical strategy for preterm birth within 7 days in threatened preterm labor women.The EPMA journal · 2022Article
- Effects of maternal ritodrine hydrochloride administration on the heart rate of preterm fetal sheep with intraamniotic inflammation.PloS one · 2022Article
- Preterm birth update in Australasia: A report of the international symposium of Preterm Birth International Collaborative-Australasia branch.Frontiers in pediatrics · 2022Review
- Neonatal rebound hyperkalemia associated with ritodrine alone: a case report.BMC pediatrics · 2021Article
- Acute Pulmonary Edema Induced by a Low Dose of Ritodrine Hydrochloride: A Case Report.The Kobe journal of medical sciences · 2021Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundNo study has revealed the effectiveness of long-term tocolysis for patients diagnosed with threatened preterm birth, and the use of betamimetics in these patients has not been recommended in the United States or Europe because of the potential for severe maternal adverse effects. However, long-term tocolysis with intravenous infusion of ritodrine hydrochloride, a betamimetic, can be selected as the first-line tocolytic treatment in Japan. This study was performed to (i) examine the current status of long-term tocolytic treatment, particularly with intravenous infusion of betamimetics, for threatened preterm birth in Japan and (ii) clarify the association between long-term tocolytic treatment and maternal adverse effects.
methodsThis retrospective cohort study was conducted using a national inpatient database for acute-care inpatients in Japan. Among all pregnant women who were diagnosed with threatened preterm birth and admitted to the hospital from July 2010 to March 2016, we identified 134,959 eligible patients. The primary outcome was maternal serious adverse effects during hospitalization. A multivariable logistic regression analysis was performed to evaluate factors associated with maternal adverse effects.
resultsAmong all patients, 17.2% received intravenous infusion of ritodrine hydrochloride for ≤48 h and 28.7% received this treatment for ≥28 days. The proportion of maternal adverse effects was significantly higher among patients treated for ≥28 days than ≤48 h. A longer duration of tocolysis was significantly associated with increased maternal adverse effects.
conclusionsLong-term tocolysis was associated with an increased incidence of maternal adverse effects in the current study using real-world data. Japanese clinicians should adjust their tocolytic treatment practices in accordance with the latest scientific evidence or make efforts to verify the effectiveness and safety of long-term tocolysis.
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