Trial reportBMC oral health2019
Randomized investigation of the bioavailability of fluoride in saliva after administration of sodium fluoride, amine fluoride and fluoride containing bioactive glass dentifrices.
Trial report in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Diurnal and nocturnal salivary fluoride bioavailability following brushing with high- or regular-fluoride dentifrices.European journal of oral sciences · 2026Trial
- Plaque and Salivary Fluoride Levels in Preschoolers Following Applications of Silver Diamine Fluoride, Sodium Fluoride Varnish, and Their Combination: A Randomized Clinical Trial.International journal of paediatric dentistry · 2026Trial
- Cytotoxicity and Genotoxicity of Fluoride Toothpastes in Buccal Cells.Acta stomatologica Croatica · 2026Article
- A novel dual-targeting strategy to suppress cariogenic bacteria and biofilms with engineered ARG/FBG bioactive composites.Regenerative biomaterials · 2026Article
- Fundamentals of Nonparametric Statistical Tests for Dental Clinical Research.Dentistry journal · 2024Review
- Comparative evaluation of remineralization potential of novel bioactive agents on eroded enamel lesions: A single-blindedJournal of conservative dentistry and endodontics · 2024Article
- Evaluation of toothpastes for treating root carious lesions - a laboratory-based pilot study.BMC oral health · 2024Article
- Bioactive Materials for Caries Management: A Literature Review.Dentistry journal · 2023Review
- Comparative Efficacy of Novel Biomimetic Remineralising Technologies.Biomimetics (Basel, Switzerland) · 2023Article
- Nocturnal Salivary Fluoride Bioavailability After Brushing with a High-fluoride Dentifrice.Biological trace element research · 2022Article
- Salivary Fluoride Bioavailability after Brushing with Brazilian Red Propolis Dentifrice: A Clinical Study.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Enamel Remineralization Competence of a Novel Fluoride-Incorporated Bioactive Glass Toothpaste-A Surface Micro-Hardness, Profilometric, and Micro-Computed Tomographic Analysis.Tomography (Ann Arbor, Mich.) · 2021Article
- A Potassium Based Fluorine Containing Bioactive Glass for Use as a Desensitizing Toothpaste.Molecules (Basel, Switzerland) · 2021Article
- Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Comparative Analysis of Application of Fluoride Bioactive Glass and Sodium Fluoride Toothpastes for Remineralization of Primary Tooth Enamel Lesions.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBioactive glasses which degrade in aqueous solutions may release bioactive ions such as fluoride (F MATERIAL AND
methodsIn this single-center, randomized, parallel in vivo trial with a three strata block design, where healthy subjects were randomly assigned into three groups. Each group brushed their teeth either with fluoridated bioactive glass containing dentifrice, with a sodium fluoride (NaF) containing dentifrice or with amine fluoride (AmF) containing toothpaste. Saliva was collected time intervals before, immediately after, 30, 60 and 120 min after toothbrushing. Fluoride concentration was determined in supernatant saliva and salivary sediment using a fluoride ion selective electrode. The data were evaluated statistically using non-parametric tests.
resultsThe increase of bioactive fluoride in supernatant saliva was higher after application of NaF or AmF compared to fluoridated bioactive glass. In salivary sediment bioavailability of fluoride lasted longer after application of fluoridated bioactive glass.
conclusionsToothbrushing with the fluoride containing bioactive glass dentifrices had positive effects on the fluoride bioavailability within two hours. Fluoride containing bioactive glass represent a new area for investigation in caries prophylaxis. The bioactive potential impact on the tooth remineralization should be examined further.
trial registrationDRKS00016038 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.