Trial reportBMC anesthesiology2019
Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO
Trial report in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02054143 (The Effect of Sevoflurane on Cerebral Vasoreactivity Ans Systemic Arteries), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Sevoflurane on Cerebral Vasoreactivity Ans Systemic Arteries
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Tale of Two Cities: narrative review of oxygen.F1000Research · 2023Pooled it
- Effects of noradrenaline and phenylephrine on cerebral oxygen saturation during cardiopulmonary bypass in cardiac surgery.Experimental physiology · 2025Trial
- Effect of dexmedetomidine on dynamic cerebral autoregulation and carbon dioxide reactivity during sevoflurane anesthesia in healthy patients.Korean journal of anesthesiology · 2020Trial
- Cerebral hemodynamics, autoregulation, and neurocognitive outcomes during Trendelenburg positioning in robot-assisted abdominopelvic surgery: a narrative review.Journal of robotic surgery · 2026Review
- Association Between Entropy Monitoring, Burst Suppression and Early Postoperative Cognitive Dysfunction in Emergency Surgery: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Relationship between volatile anesthetics and functional outcomes in patients with subarachnoid hemorrhage.Journal of anesthesia, analgesia and critical care · 2025Article
- Comparison of Cerebral Blood Flow During General Anesthesia in Elderly Patients with and Without Dementia: A Prospective Controlled Clinical Trial.Journal of clinical medicine · 2025Article
- Anesthetics in pathological cerebrovascular conditions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Review
- Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans,Neuroimage. Reports · 2024Article
- Prospective Observational Study of Volatile Sedation with Sevoflurane After Aneurysmal Subarachnoid Hemorrhage Using the Sedaconda Anesthetic Conserving Device.Neurocritical care · 2024Observational
- Impact of Stepwise Recruitment Maneuvers on Cerebral Hemodynamics: Experimental Study in Neonatal Model.Journal of personalized medicine · 2023Article
- Risk of overestimating loss of cerebral autoregulation.BJA open · 2022Article
- Change in the optic nerve sheath diameter after deflation of a pneumatic tourniquet: a prospective observational study.Scientific reports · 2022Observational
- Anesthesia-Induced Oxidative Stress: Are There Differences between Intravenous and Inhaled Anesthetics?Oxidative medicine and cellular longevity · 2021Review
- Anesthetic Agents Isoflurane and Propofol Decrease Maximal CaThe Journal of pharmacology and experimental therapeutics · 2019Article
- The effect of propofol-sufentanil intravenous anesthesia on systemic and cerebral circulation, cerebral autoregulation and COBrazilian journal of anesthesiology (Elsevier)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevoflurane is one of the most frequently used inhaled anesthetics for general anesthesia. Previously it has been reported that at clinically used doses of sevoflurane, cerebral vasoreactivity is maintained. However, there are no data how sevoflurane influences systemic and cerebral circulation in parallel. The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO
methodsTwenty nine patients undergoing general anesthesia were enrolled. Anesthesia was maintained with 1 MAC sevoflurane in 40% oxygen. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35 and 30 mmHg EtCO
resultsSystemic mean arterial pressure significantly decreased during anesthetic induction and remained unchanged during the entire study period. Central aortic and peripherial pulse pressure and augmentation index as markers of arterial stiffness significantly increased during the anesthetic induction and remained stable at the time points when target CO DISCUSSION: Cerebral autoregulation and CO
trial registrationThe study was registered at http://www.clinicaltrials.gov , identifier: NCT02054143, retrospectively registered. Date of registration: February 4, 2014.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.