ArticleJournal of neurophysiology2019
Pairing vagus nerve stimulation with tones drives plasticity across the auditory pathway.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Bimodal Stimulation of the Auditory-Somatosensory System Improves Auditory Sensory Gating Function in Patients with Tinnitus.Journal of the American Academy of Audiology · 2026Trial
- Vagus Nerve Stimulation Paired With Tones Alters the Auditory Cortex Proteome in a Rat Model of Rett Syndrome.Developmental neurobiology · 2026Article
- Enhanced neural plasticity of the primary visual cortex in visual snow syndrome: evidence from magnetoencephalographic gamma oscillations.Brain communications · 2026Article
- Therapeutic potential of vagus nerve stimulation in neurodegenerative diseases: research progress and mechanisms.Frontiers in immunology · 2026Review
- Vagus nerve stimulation modulates cocaine seeking induced synaptic plasticity in reward related brain circuits.Scientific reports · 2025Article
- Vagus nerve stimulation modulates synaptic plasticity induced by cocaine- seeking in reward-related circuitry.Research square · 2025Article
- Vagus Nerve Stimulation in Stroke Management: Brief Review of Evolution and Present Applications Paired with Rehabilitation.Brain sciences · 2025Review
- Speech paired vagus nerve stimulation restores neural sound processing in a rat model of autism.Frontiers in neuroscience · 2025Article
- Vagus nerve stimulation (VNS): recent advances and future directions.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Pairing tones with vagus nerve stimulation improves brain stem responses to speech in the valproic acid model of autism.Journal of neurophysiology · 2024Article
- Vagus nerve stimulation during training fails to improve learning in healthy rats.Scientific reports · 2024Article
- Article
- Degraded inferior colliculus responses to complex sounds in prenatally exposed VPA rats.Journal of neurodevelopmental disorders · 2024Article
- The sound stimulation method and EEG change analysis for development of digital therapeutics that can stimulate the nervous system: Cortical activation and drug substitution potential.CNS neuroscience & therapeutics · 2023Article
- Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing.Frontiers in neuroscience · 2023Article
- Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications.Frontiers in neuroscience · 2023Review
- Timing of vagus nerve stimulation during fear extinction determines efficacy in a rat model of PTSD.Scientific reports · 2022Article
- Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder.Journal of psychiatry and brain science · 2022Article
- Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity.Scientific reports · 2021Article
- Alternation of Neuronal Feature Selectivity Induced by Paired Optogenetic-Mechanical Stimulation in the Barrel Cortex.Frontiers in neural circuits · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have demonstrated that pairing vagus nerve stimulation (VNS) with sounds can enhance the primary auditory cortex (A1) response to the paired sound. The neural response to sounds following VNS-sound pairing in other subcortical and cortical auditory fields has not been documented. We predicted that VNS-tone pairing would increase neural responses to the paired tone frequency across the auditory pathway. In this study, we paired VNS with the presentation of a 9-kHz tone 300 times a day for 20 days. We recorded neural responses to tones from 2,950 sites in the inferior colliculus (IC), A1, anterior auditory field (AAF), and posterior auditory field (PAF) 24 h after the last pairing session in anesthetized rats. We found that VNS-tone pairing increased the percentage of IC, A1, AAF, and PAF that responds to the paired tone frequency. Across all tested auditory fields, the response strength to tones was strengthened in VNS-tone paired rats compared with control rats. VNS-tone pairing reduced spontaneous activity, frequency selectivity, and response threshold across the auditory pathway. This is the first study to document both cortical and subcortical plasticity following VNS-sound pairing. Our findings suggest that VNS paired with sound presentation is an effective method to enhance auditory processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.