SynthesisJournal of the American Heart Association2019
Early Versus Delayed Stroke After Cardiac Surgery: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State - CERBERUS Trial
Perioperative Cerebral Function Assessment for Cardiac Surgery
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparison of Meta-Analytical Estimates Between Surgical Repair and Transcatheter Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation.Interdisciplinary cardiovascular and thoracic surgery · 2026Pooled it
- Potential Markers of Neurocognitive Disorders After Cardiac Surgery: A Bibliometric and Visual Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Early Versus Delayed Stroke After Cardiac Surgery: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2019Pooled it
- Effect of routine preoperative screening for aortic calcifications using noncontrast computed tomography on stroke rate in cardiac surgery: the randomized controlled CRICKET study.European radiology · 2022Trial
- Near-infrared spectroscopy device selection affects intervention management for cerebral desaturation during cardiopulmonary bypass surgery.General thoracic and cardiovascular surgery · 2022Trial
- New-onset postoperative atrial fibrillation management and outcomes: the VISION Cardiac Surgery cohort.European heart journal · 2026Article
- Machine Learning-Enhanced TCAB Score for Predicting Postoperative Ischemic Stroke After CABG.Journal of the American Heart Association · 2026Article
- Prolonged Systemic Inflammatory Response Syndrome Predicts Atrial Fibrillation After Cardiac Surgery.Interdisciplinary cardiovascular and thoracic surgery · 2026Observational
- Routine preoperative screening computed tomography of the thorax for cardiac surgery.Singapore medical journal · 2026Article
- Risk assessment in cardiac surgery: Exploring machine learning and laboratory indices as adjunctive tools.PloS one · 2026Article
- Hemodynamic changes in supra-aortic trunks after transcatheter aortic valve implantation at duplex ultrasound examination.European heart journal. Imaging methods and practice · 2025Article
- The off-pump coronary artery bypass grafting has favorable effect on neurological causes of mortality.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Acute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021.Neurology · 2025Article
- Article
- Clinical and subclinical acute brain injury caused by invasive cardiovascular procedures.Nature reviews. Cardiology · 2025Review
- A novel generative multi-task representation learning approach for predicting postoperative complications in cardiac surgery patients.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Acute Ischemic and Hemorrhagic Cerebrovascular Strokes After Cardiac Surgery: Incidence, Predictors, and Outcomes.Critical care research and practice · 2025Article
- Low-flow perfusion technique for shaggy aortic arch.General thoracic and cardiovascular surgery · 2024Article
- Cancer and the risk of perioperative arterial ischaemic events.European heart journal. Quality of care & clinical outcomes · 2024Article
- Probiotics relieve perioperative postoperative cognitive dysfunction induced by cardiopulmonary bypass through the kynurenine metabolic pathway.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Although it is traditionally regarded as a single entity, perioperative stroke comprises 2 separate phenomena (early/intraoperative and delayed/postoperative stroke). We aimed to systematically evaluate incidence, risk factors, and clinical outcome of early and delayed stroke after cardiac surgery. Methods and Results A systematic review ( MEDLINE , EMBASE , Cochrane Library) was performed to identify all articles reporting early (on awakening from anesthesia) and delayed (after normal awakening from anesthesia) stroke after cardiac surgery. End points were pooled event rates of stroke and operative mortality and incident rate of late mortality. Thirty-six articles were included (174 969 patients). The pooled event rate for early stroke was 0.98% (95% CI 0.79% to 1.23%) and was 0.93% for delayed stoke (95% CI 0.77% to 1.11%; P=0.68). The pooled event rate of operative mortality was 28.8% (95% CI 17.6% to 43.4%) for early and 17.9% (95% CI 14.0% to 22.7%) for delayed stroke, compared with 2.4% (95% CI 1.9% to 3.1%) for patients without stroke ( P<0.001 for early versus delayed, and for perioperative stroke, early stroke, and delayed stroke versus no stroke). At a mean follow-up of 8.25 years, the incident rate of late mortality was 11.7% (95% CI 7.5% to 18.3%) for early and 9.4% (95% CI 5.9% to 14.9%) for delayed stroke, compared with 3.4% (95% CI 2.4% to 4.8%) in patients with no stroke. Meta-regression demonstrated that off-pump was inversely associated with early stroke (β=-0.009, P=0.01), whereas previous stroke (β=0.02, P<0.001) was associated with delayed stroke. Conclusions Early and delayed stroke after cardiac surgery have different risk factors and impacts on operative mortality as well as on long-term survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.