Observational studyInternational journal of cancer2020
Cervical cancer risk in women living with HIV across four continents: A multicohort study.
Abstract readMulticenter StudyObservational Study
In one paragraph
Observational study in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cervical cancer prevention in countries with the highest HIV prevalence: a review of policies.BMC public health · 2022Pooled it
- Paracrine signals from HIV-1-infected immune cells reprogram cervical cancer pathways.iScience · 2026Article
- Article
- Understanding Cervical Cancer Screening Intentions Through the Lens of Care-Seeking Behavior: A Cross-Sectional Study Among Islamic Women in Ghana.Health science reports · 2026Article
- Factors associated with uptake of gynaecological care and cervical cancer screening among women in the Swiss HIV Cohort Study.HIV medicine · 2025Article
- Prevalence and predictors of cervical lesions among women on ART in the Awi Zone, Northwest Ethiopia: facility-based cross-sectional study.BMC women's health · 2025Article
- Incidence and outcomes of anal and cervical cancer among adults with HIV in Latin America: a retrospective cohort study.Journal of the International AIDS Society · 2025Article
- High Burden of Symptomatic and Asymptomatic Sexually Transmitted Infections in a Routine Decentralised HIV Care Setting in Eswatini: A Cross-Sectional Study.Tropical medicine & international health : TM & IH · 2025Article
- Review
- Feasibility of First-Void Urinary and Vaginal Self-Sampling for High-Risk Human Papillomavirus Testing Among Women Living With Human Immunodeficiency Virus in Guinea-Bissau-A Multicenter Cross-Sectional Study.Journal of medical virology · 2025Article
- Cervical dysplasia in women with HIV in the modern treat-all era: elevated risk remains despite long-term ART and normal CD4 + cell count.AIDS (London, England) · 2025Article
- Client perspectives and satisfaction with integrating facility and community-based HPV self-sampling for cervical cancer screening with family planning: a mixed method study.BMC public health · 2025Article
- High burden of human papillomavirus and premalignant cervical lesions among women starting HIV treatment in KwaZulu-Natal, South Africa.Sexually transmitted infections · 2025Article
- Prevalence and risk factors of high-risk HPV and cervical abnormalities in HIV-positive women in Bali, Indonesia.BMC infectious diseases · 2025Article
- Barriers and facilitators to the integration of cervical cancer screening and treatment service with antiretroviral therapy follow-up clinics for women living with HIV in Northwest Ethiopia: a qualitative study.Frontiers in public health · 2025Article
- 'ARVs is for HIV and cream is for HPV or precancer:' Women's perceptions and perceived acceptability of self-administered topical therapies for cervical precancer treatment: a qualitative study from Kenya.Ecancermedicalscience · 2025Article
- A review of urinary HPV testing for cervical cancer management and HPV vaccine surveillance: rationale, strategies, and limitations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Review
- State of the science and future directions for research on HIV and cancer: Summary of a joint workshop sponsored by IARC and NCI.International journal of cancer · 2024Review
- Cost-effectiveness of single-visit cervical cancer screening in KwaZulu-Natal, South Africa: a model-based analysis accounting for the HIV epidemic.Frontiers in oncology · 2024Article
- HIV prevalence among cervical (pre)cancer diagnoses in Suriname: a retrospective population study.Revista panamericana de salud publica = Pan American journal of public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors.
Eliane RohnerInstitute of Social and Preventive Medicine, University of Bern, Switzerland.ORCID 0000-0002-0554-2875
Lukas BütikoferCTU Bern, University of Bern, Switzerland.
Kurt SchmidlinInstitute of Social and Preventive Medicine, University of Bern, Switzerland.
Mazvita SengayiNational Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.
Mhairi MaskewHealth Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Janet GiddyDepartment of Medicine, McCord Hospital, Durban, South Africa.
Katayoun TaghaviInstitute of Social and Preventive Medicine, University of Bern, Switzerland.
Richard D MooreJohns Hopkins University, School of Medicine, Baltimore, Maryland.
James J GoedertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
M John GillUniversity of Calgary, Alberta, Canada.
Michael J SilverbergDivision of Research, Kaiser Permanente Northern California, Oakland, USA.
Gypsyamber D'SouzaJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Pragna PatelDivision of Global HIV and TB, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jessica L CastilhoDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, USA.
Jeremy RossTREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Annette SohnTREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Firouze Bani-SadrReims Champagne-Ardenne University, Faculté de médecine, CHU Reims, Hôpital Robert Debré, Tropical and Infectious Diseases, Reims, France.
Ninon TaylorIIIrd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectious Diseases and Rheumathology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.
Vassilios PaparizosAIDS Unit, Clinic of Venereologic and Dermatologic Diseases, Athens Medical School, "Syngros" Hospital, Athens, Greece.
Fabrice BonnetCHU de Bordeaux, Service de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, Bordeaux, France.
Annelies VerbonDepartment Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
Jörg Janne VehreschildDepartment I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Frank A PostKing's College Hospital NHS Foundation Trust, London, UK.
Caroline SabinInstitute for Global Health, UCL, London, United Kingdom.
Amanda MocroftInstitute for Global Health, UCL, London, United Kingdom.
Fernando DrondaDepartment of Infectious Diseases, Hospital Ramón y Cajal, Madrid, Spain.
Niels ObelDepartment of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark.
Sophie GrabarSorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France.
Vincenzo SpagnuoloVita-Salute San Raffaele University, Faculty of Medicine and Surgery, Milan, Italy.
Eugenia Quiros-RoldanInfectious and Tropical Diseases Institute, University of Brescia, Brescia, Italy.
Cristina MussiniInfectious Diseases Clinics, University Hospital, Modena, Italy.
José M MiroInfectious Diseases Service, Hospital Clinic - IDIBAPS, University of Barcelona, Barcelona, Spain.
Laurence MeyerINSERM, U1018, Epidemiology of HIV, Reproduction, Paediatrics, CESP, University Paris-Sud, Paris, France.
Barbara HasseDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland.
Deborah KonopnickiDepartment of Infectious Diseases, St Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Bernardino RocaHospital General Universitario, Castellón, Spain.
Diana BargerUniv. Bordeaux, ISPED, Centre INSERM U1219-Bordeaux Population Health, F-33000 Bordeaux, France.
Gary M CliffordInternational Agency for Research on Cancer, Lyon, France.
Silvia FranceschiCentro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Matthias EggerInstitute of Social and Preventive Medicine, University of Bern, Switzerland.ORCID 0000-0001-7462-5132
Julia BohliusInstitute of Social and Preventive Medicine, University of Bern, Switzerland.
Funding
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6MWOMEN'S HEALTH AGENDAU01AI038858 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI BENSON, CONSTANCE ANN · 1996 to 2008
$157.5MAIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1MUCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2MUniversity of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9MUnsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4MVirology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MVirology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1MSTATISTICAL AND DATA MANAGEMENT CENTERU01AI038855 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HUGHES, MICHAEL DAVID · 1996 to 2006
$78.1MEngaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MStudies of Ocular Complications of AIDS - Coordinating CenterU10EY008057 · NEI · JOHNS HOPKINS UNIVERSITY · PI VAN NATTA, MARK L · 1988 to 2012
$78.0MVirology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9MCDC HHS CDC-200-2006-18797CDC HHS CDC-200-2015-63931HRSA HHS 90051652Intramural CDC HHS CC999999Intramural NIH HHS Z01 CP010176Medical Research Council MR/M004236/1NCATS NIH HHS KL2 TR000421NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000083NCATS NIH HHS UL1 TR000454NCI NIH HHS N01 CP001004NCI NIH HHS N02 CP055504NCI NIH HHS R01 CA165937NCRR NIH HHS M01 RR000052NCRR NIH HHS UL1 RR024131NEI NIH HHS K23 EY013707NEI NIH HHS U10 EY008052NEI NIH HHS U10 EY008057NEI NIH HHS U10 EY008067NIAAA NIH HHS R01 AA016893NIAAA NIH HHS U01 AA013566NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U24 AA020794NIAID NIH HHS K01 AI093197NIAID NIH HHS K23 AI120875NIAID NIH HHS K24 AI065298NIAID NIH HHS K24 AI118591NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI036219NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI094189NIAID NIH HHS P30 AI110527NIAID NIH HHS R24 AI067039NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI037613NIAID NIH HHS U01 AI037984NIAID NIH HHS U01 AI038855NIAID NIH HHS U01 AI038858NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI068634NIAID NIH HHS U01 AI068636NIAID NIH HHS U01 AI069432NIAID NIH HHS U01 AI069434NIAID NIH HHS U01 AI069907NIAID NIH HHS U01 AI069918NIAID NIH HHS U01 AI069923NIAID NIH HHS U01 AI069924NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NIAID NIH HHS UM1 AI035043NIAID NIH HHS UM1 AI068634NIA NIH HHS R01 AG053100NICHD NIH HHS U01 HD032632NIDA NIH HHS F31 DA037788NIDA NIH HHS K24 DA000432NIDA NIH HHS R01 DA011602NIDA NIH HHS R01 DA012568NIDA NIH HHS U01 DA036935NIH HHS F31AI124794NIH HHS F31DA037788NIH HHS G12MD007583NIH HHS K01AI093197NIH HHS K01AI131895NIH HHS K23AI120875NIH HHS K23EY013707NIH HHS K24AI065298NIH HHS K24AI118591NIH HHS K24DA000432NIH HHS KL2TR000421NIH HHS M01RR000052NIH HHS N01CP01004NIH HHS N02CP055504NIH HHS N02CP91027NIH HHS P30AI027757NIH HHS P30AI027763NIH HHS P30AI027767NIH HHS P30AI036219NIH HHS P30AI050410NIH HHS P30AI094189NIH HHS P30AI110527NIH HHS P30MH62246NIH HHS R01AA016893NIH HHS R01 AG053100NIH HHS R01CA165937NIH HHS R01DA011602NIH HHS R01DA012568NIH HHS R24AI067039NIH HHS U01AA013566NIH HHS U01AA020790NIH HHS U01AI031834NIH HHS U01AI034989NIH HHS U01AI034993NIH HHS U01AI034994NIH HHS U01AI035004NIH HHS U01AI035039NIH HHS U01AI035040NIH HHS U01AI035041NIH HHS U01AI035042NIH HHS U01AI037613NIH HHS U01AI037984NIH HHS U01AI038855NIH HHS U01AI038858NIH HHS U01AI042590NIH HHS U01AI068634NIH HHS U01AI068636NIH HHS U01AI069432NIH HHS U01AI069434NIH HHS U01AI069918NIH HHS U01AI103390NIH HHS U01AI103397NIH HHS U01AI103401NIH HHS U01AI103408NIH HHS U01DA03629NIH HHS U01DA036935NIH HHS U01HD032632NIH HHS U10EY008052NIH HHS U10EY008057NIH HHS U10EY008067NIH HHS U24AA020794NIH HHS U54MD007587NIH HHS UL1RR024131NIH HHS UL1TR000004NIH HHS UL1TR000083NIH HHS UL1TR000454NIH HHS UM1AI035043NIH HHS Z01CP010176NIH HHS Z01CP010214NIMHD NIH HHS G12 MD007583NIMHD NIH HHS U54 MD007587NIMH NIH HHS P30 MH062246World Health Organization 001
Abstract
We compared invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin and North America among women living with HIV who initiated antiretroviral therapy (ART) between 1996 and 2014. We analyzed cohort data from the International Epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. We used flexible parametric survival models to determine regional ICC rates and risk factors for incident ICC. We included 64,231 women from 45 countries. During 320,141 person-years (pys), 356 incident ICC cases were diagnosed (Europe 164, South Africa 156, North America 19 and Latin America 17). Raw ICC incidence rates per 100,000 pys were 447 in South Africa (95% confidence interval [CI]: 382-523), 136 in Latin America (95% CI: 85-219), 76 in North America (95% CI: 48-119) and 66 in Europe (95% CI: 57-77). Compared to European women ICC rates at 5 years after ART initiation were more than double in Latin America (adjusted hazard ratio [aHR]: 2.43, 95% CI: 1.27-4.68) and 11 times higher in South Africa (aHR: 10.66, 95% CI: 6.73-16.88), but similar in North America (aHR: 0.79, 95% CI: 0.37-1.71). Overall, ICC rates increased with age (>50 years vs. 16-30 years, aHR: 1.57, 95% CI: 1.03-2.40) and lower CD4 cell counts at ART initiation (per 100 cell/μl decrease, aHR: 1.25, 95% CI: 1.15-1.36). Improving access to early ART initiation and effective cervical cancer screening in women living with HIV should be key parts of global efforts to reduce cancer-related health inequities.
Indexed as
Health Status DisparitiesAdolescentAdultAge FactorsAnti-Retroviral AgentsCD4 Lymphocyte CountCross-Cultural ComparisonEarly Detection of CancerEuropeFemaleFollow-Up StudiesHIV InfectionsHumansIncidenceLatin AmericaMiddle AgedAnti-Retroviral Agentscervical cancercohort studyHIVincidence rate
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