Evidence map›Paper›PMID 31214942›Full record

ReviewCurrent obesity reports2019

Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk.

George A Bray, Ronald M Krauss, Frank M Sacks, Lu Qi

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current obesity reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04699448 (Genetic Predisposition and Body Weight Regulation. Evaluation of Target-genes in Overweight and Obese Adults, Under Different Dietary Interventions.), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04699448 nacompletednot on this mapstarted 2020, after this paper: background citation

Genetic Predisposition and Body Weight Regulation. Evaluation of Target-genes in Overweight and Obese Adults, Under Different Dietary Interventions.

TypeinterventionalSponsorHarokopio UniversityRan2020 to 2021Enrolled202ConditionsGene-diet Interactions, Overweight and Obesity, Body Weight Changes, Health StatusArmsNutritional intervention.
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

George A BrayPennington Biomedical Research Center Baton Rouge, Baton Rouge, LA, USA. George.bray@pbrc.edu.
Ronald M KraussChildren's Hospital Oakland Research Institute, Oakland, CA, USA.
Frank M SacksHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Lu QiHarvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

National Heart, Lung, and Blood Institute N/A
6 · The paper itself

Abstract

purpose of reviewThis paper reviews the genetic and non-genetic factors that provided predictions of, or were associated with, weight loss and other metabolic changes in the POUNDS Lost clinical trial of weight loss. This trial randomized 811 individuals who were overweight or obese to one of four diets that contained either 15% or 25% protein and 20% or 40% fat in a 2 × 2 factorial design. A standard behavioral weight loss program was available for all participants who were followed for 2 years with an 80% completion rate. RECENT

findingsNineteen genes and five genetic risk scores were used along with demographic, behavioral, endocrine, and metabolic measurements. Genetic variations in most of the genes were associated with weight loss, but this association often varied with the dietary assignment. A number of demographic and behavioral factors, including attendance at behavioral sessions and food cravings were predictive of weight changes. A high baseline level of free triiodothyronine or free thyroxine predicted the magnitude of weight loss. Several perfluoroakyl compounds predicted more rapid weight regain. Genetic evidence from POUNDS Lost provides guidance toward selection of a personalized weight loss diet and improvement in metabolic profile. There is still room for additional research into the predictors of weight loss.

Indexed as

AdultAgedBehaviorBody CompositionBody Mass IndexBody WeightCardiovascular DiseasesFemaleGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedObesityGenetic MarkersBehavioral markersDemographic markersGenetic markersMetabolic markersPOUNDS Lost Clinical Trial

Identifiers

PMID31214942

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.