SynthesisCurrent neurology and neuroscience reports2019
Functional MRI to Study Gait Impairment in Parkinson's Disease: a Systematic Review and Exploratory ALE Meta-Analysis.
Synthesis in Current neurology and neuroscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Repeated Gait Perturbation Training in Parkinson's Disease and Healthy Older Adults: A Systematic Review and Meta-Analysis.Frontiers in human neuroscience · 2021Pooled it
- Visual perturbation training to reduce visual dependency in Parkinson's disease: A randomized controlled trial.PloS one · 2026Trial
- A Randomized, Controlled Trial of Exercise for Parkinsonian Individuals With Freezing of Gait.Movement disorders : official journal of the Movement Disorder Society · 2020Trial
- Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: Study Protocol of the International AnTi-FREEZE Study.The European journal of neuroscience · 2026Article
- Longitudinal changes in effective connectivity associated with worsening freezing of gait in Parkinson's disease: a resting-state functional MRI study.Journal of neurology · 2026Observational
- Self-delivered arousal-heightening stimuli to improve mobility in persons with parkinsonism: A case series.Journal of Parkinson's disease · 2026Article
- Foot-Tapping fMRI-Guided rTMS Enhances Motor and Cognitive Functions in Parkinson's Disease: A Three-Year Follow-Up.Movement disorders clinical practice · 2025Article
- An Exploratory Analysis of Rhythmic Auditory Stimulation's Impact on Brain Function in Parkinson's Disease Patients With Freezing of Gait.Brain and behavior · 2025Article
- GAMMA-PD: Graph-based Analysis of Multi-Modal Motor Impairment Assessments in Parkinson's Disease.Graphs in biomedical image analysis : 6th International Workshop, GRAIL 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 6, 2024, Proceedings. GRAIL (Workshop) (6th : 2024 : Marrakesh, Morocco) · 2025Article
- Neural correlates of bradykinesia in Parkinson's disease: a kinematic and functional MRI study.NPJ Parkinson's disease · 2024Article
- Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson's disease.American journal of translational research · 2024Article
- Development and implementation of the frog-in-maze game to study upper limb movement in people with Parkinson's disease.Scientific reports · 2023Article
- Compensation Strategies for Gait Impairments in Parkinson's Disease: From Underlying Mechanisms to Daily Clinical Practice.Movement disorders clinical practice · 2023Article
- Modulating arousal to overcome gait impairments in Parkinson's disease: how the noradrenergic system may act as a double-edged sword.Translational neurodegeneration · 2023Review
- Gait-Related Metabolic Covariance Networks at Rest in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Stepping up to meet the challenge of freezing of gait in Parkinson's disease.Translational neurodegeneration · 2022Review
- Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson's disease.Scientific reports · 2022Article
- Freezing of gait: overview on etiology, treatment, and future directions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Freezing of Gait in Multiple System Atrophy.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewWhilst gait impairment is a main cause for disability in Parkinson's disease (PD), its neural control remains poorly understood. We performed a systematic review and meta-analysis of neuroimaging studies of surrogate features of gait in PD.
findingsAssessing the results from PET or SPECT scans after a period of actual walking as well as fMRI during mental imagery or virtual reality (VR) gait paradigms, we found a varying pattern of gait-related brain activity. Overall, a decrease in activation of the SMA during gait was found in PD compared to elderly controls. In addition, the meta-analysis showed that the most consistent gait-related activation was situated in the cerebellar locomotor region (CLR) in PD. Despite methodological heterogeneity, the combined neuroimaging studies of gait provide new insights into its neural control in PD, suggesting that CLR activation likely serves a compensatory role in locomotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.