ArticleInternational ophthalmology2019
Therapeutic penetrating keratoplasty for acanthamoeba keratitis: a review of cases, complications and predictive factors.
Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Severe corneal melting with necrotic sloughing in Acanthamoeba keratitis mimicking corneal endotheliitis.Journal of ophthalmic inflammation and infection · 2026Article
- Prognostic factors for therapeutic keratoplasty in Acanthamoeba keratitis: a retrospective study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Dysregulated Intraocular Pressure in Acanthamoeba Keratitis: Clinical Associations, Therapy, and Prognosis.Microorganisms · 2026Article
- Article
- Corneal collagen cross-linking combined with lamellar keratoplasty in the treatment of Acanthamoeba keratitis.International ophthalmology · 2025Article
- Complicated Diagnosis and Treatment of Rare PainlessJournal of clinical medicine · 2025Article
- Acanthamoeba Keratitis Management and Prognostic Factors: A Systematic Review.Journal of clinical medicine · 2025Review
- Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection.Microorganisms · 2024Review
- Comparison of therapeutic effects between big-bubble deep anterior lamellar keratoplasty and penetrating keratoplasty for medically unresponsive Acanthamoeba keratitis.BMC infectious diseases · 2024Article
- Tectonic and Therapeutic Urgent Penetrating Keratoplasty Outcomes.Beyoglu eye journal · 2024Article
- New Frontiers inBiology · 2023Review
- The role of the calcofluor white staining in the diagnosis of Acanthamoeba keratitis.Journal of ophthalmic inflammation and infection · 2023Article
- Challenges in Acanthamoeba Keratitis: A Review.Journal of clinical medicine · 2021Review
- Optimizing early diagnosis and treatment of acanthamoeba keratitis through corneal scraping.Journal of optometryArticle
- Parasitic keratitis - An under-reported entity.Tropical parasitologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review 12 acanthamoeba keratitis (AK) patients who required a therapeutic penetrating keratoplasty (TPK) and determine whether there are factors at the presenting visit that can predict the need for TPK. MATERIALS AND
methodsThis was a retrospective case series. All diagnosed AK patients between January, 2009 and February, 2016 at Wills Eye Hospital, Philadelphia, PA, USA, were enrolled. Information regarding demographics, disease manifestation, management and complications was collected. Potential predictors for TPK were obtained by comparing TPK cases with those who were treated medically.
resultsSixty-three eyes from 63 patients were diagnosed with AK. Twelve eyes (19%) required TPK during the course of treatment, and 51 eyes (81%) were treated medically. Reasons for performing TPK included medically non-responsive ulcer in seven eyes (58%), perforated ulcer in three eyes (25%) and significant corneal thinning in two eyes (17%). The most common post-TPK complications included graft failure (75%), cataract (50%) and uncontrolled glaucoma required glaucoma surgery (17%). Reactivation of AK was seen in one (8%) patient. Anti-amoebic treatment beginning after 25 days from the start of AK symptoms [odds ratio (OR) = 7.63; confidence interval (CI) = 1.01-55.33; p = 0.041] and poorer presenting vision (OR = 5.42; CI = 1.91-15.36; p = 0.002) were independent predictors of the need for TPK in multivariate analysis.
conclusionTPK is a procedure with significant postoperative complications but is required by some patients with AK. Eyes with higher risk for needing TPK can be identified earlier and thus provided more intensive treatment and closer follow-up care.
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