ArticleJournal of bone and mineral metabolism2019
The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women.
Article in Journal of bone and mineral metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Sites of non-enzymatic crosslinks pentosidine and glucosepane in collagen I of human cortical bone.Bone · 2026Article
- Efficacy of romosozumab followed by denosumab in glucocorticoid users; a randomized clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Pentosidine and Bone Properties in Autosomal Dominant Polycystic Kidney Disease.Journal of clinical medicine · 2025Article
- Association between vertebral fractures and comorbidities in patients with rheumatoid arthritis: a cross-sectional study.Journal of bone and mineral metabolism · 2025Article
- Urinary pentosidine as a potential biomarker of impaired bone health: a systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2025Review
- Frailty and osteoporotic fractures represent mutual risks for each other with common physiological backgrounds.JBMR plus · 2025Article
- Impact of frailty and prevalent fractures on the long-term prognosis of patients with cirrhosis: a retrospective study.Scientific reports · 2025Article
- Urinary pentosidine as a potential biomarker of muscle and physical performance in young adult men.Journal of physiological anthropology · 2024Article
- Article
- Association of chronic liver disease with bone diseases and muscle weakness.Journal of bone and mineral metabolism · 2024Review
- Review
- Urinary pentosidine level is associated with the risk of fracture in community-dwelling older adults: a prospective observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Observational
- Comparison of different parameters between daily and twice-weekly teriparatide in postmenopausal women with severe osteoporosis.Journal of bone and mineral metabolism · 2023Article
- The association between urinary pentosidine levels and cognition in drug-naïve patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Review
- Article
- Risk factors for incident vertebral fractures in osteoporosis pharmacotherapy: a 2-year, prospective, observational study.Journal of bone and mineral metabolism · 2021Observational
- Urinary pentosidine level is associated with grip strength and gait speed in community-dwelling adults: a cross-sectional study.BMC musculoskeletal disorders · 2021Article
- Plasma pentosidine levels are associated with prevalent fractures in patients with chronic liver disease.PloS one · 2021Article
- Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers.Scientific reports · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate whether or not the urinary pentosidine level has clinical value in the assessment of the osteoporotic fracture risk, a novel ELISA for pentosidine was used in clinical samples. This study employed a cross-sectional design to analyze a subset of postmenopausal women in the Nagano Cohort Study. A total of 517 urine samples were analyzed using an ELISA system, which can measure urinary pentosidine without hydrolysis. Patients were asked about their history of non-vertebral osteoporotic fracture and the prevalence of vertebral fracture was semi-quantitatively assessed on X-ray films. A 10-year increase in age was related to a 1.09-fold increase in the urinary pentosidine level (95% CI 1.05-1.13, P < 0.001), prevalent fracture (+) was related to a 1.10-fold increase in the urinary pentosidine level (95% CI 1.03-1.18, P = 0.006). Patients with prevalent fracture who had a normal bone mineral density (BMD) showed higher pentosidine levels (median 34.3 pM/mg Cr) than patients with a low BMD without fracture (median 31.4 pM/mg Cr). A multivariable logistic regression analysis revealed that urinary pentosidine was significantly associated with the prevalence of fracture after adjustment for known risk factors for fracture (odds ratio 1.92, 95% CI 1.09-3.37, P = 0.023). The present results indicated a significant association between urinary pentosidine and fracture after adjustment for age and BMD, suggesting that urinary pentosidine may be useful for assessing the fracture risk in postmenopausal women.
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