Evidence map›Paper›PMID 31214767›Full record

Observational studyJournal of neurology2019

Diplopia in Parkinson's disease: visual illusion or oculomotor impairment?

Femke Visser, Annemarie M M Vlaar, Carlijn D J M Borm, Valentin Apostolov, Y X Lee, Irene C Notting, Henry C Weinstein, Henk W Berendse

Open access · greenAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Femke VisserDepartment of Neurology, Onze Lieve Vrouwe Gasthuis (OLVG), Location OLVG West, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands. visser.femke@gmail.com.ORCID http://orcid.org/0000-0001-9195-2346
Annemarie M M VlaarDepartment of Neurology, Onze Lieve Vrouwe Gasthuis (OLVG), Location OLVG West, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands.
Carlijn D J M BormDepartment of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Parkinson Centre (ParC), Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Valentin ApostolovDepartment of Ophthalmology, Onze Lieve Vrouwe Gasthuis (OLVG), Location OLVG West, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands.
Y X LeeDepartment of Neurology, Maasstad Hospital, Maasstadweg 21, 3079 DZ, Rotterdam, The Netherlands.
Irene C NottingDepartment of Ophthalmology, Leids University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Henry C WeinsteinDepartment of Neurology, Onze Lieve Vrouwe Gasthuis (OLVG), Location OLVG West, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands.
Henk W BerendseDepartment of Neurology, Amsterdam UMC, Location VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
OLVG · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLLeiden University Medical Center · NLMaasstad Ziekenhuis · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionApproximately 20% of patients with Parkinson's disease (PD) experience diplopia; however, the cause of the diplopia is unclear. We aimed to explore the association of diplopia, and its subtypes, with oculomotor abnormalities, impaired vision, and visual hallucinations, in patients with PD.

methodsThis exploratory study included 41 PD patients, recruited from two general hospitals, of whom 25 had diplopia and 16 did not have diplopia, as well as 23 healthy controls (HCs). We defined subtypes of diplopia as selective diplopia, i.e., diplopia of single objects, and complete diplopia, i.e., diplopia of the entire visual field. All participants underwent a full orthoptic and ophthalmologic examination.

resultsPD patients with diplopia had a high prevalence of oculomotor abnormalities (84%), impaired vision (44%), and visual hallucinations (44%), compared to PD patients without diplopia (33%, 6%, and none, respectively, p < 0.01), and compared to HCs (23%, 9%, and none, respectively, p < 0.01). Oculomotor abnormalities were equally prevalent in both subtypes of diplopia (selective and complete), whereas impaired vision was predominantly found in patients with selective diplopia. Moreover, only patients with selective diplopia had visual hallucinations.

conclusionsIn PD patients, diplopia may be indicative of oculomotor or visual impairments. Hence, it is worthwhile to refer PD patients with diplopia to an orthoptist and an ophthalmologist for evaluation and, possibly, treatment of diplopia. Furthermore, in the case of selective diplopia, the neurologist should consider the presence of visual hallucinations, which may require the adjustment of the patient's medication.

Indexed as

AgedAged, 80 and overCross-Sectional StudiesDiplopiaFemaleHallucinationsHumansIllusionsMaleMiddle AgedOcular Motility DisordersParkinson DiseasePilot ProjectsSeverity of Illness IndexDiplopiaHallucinationsOcular disordersOcular motilityParkinson’s disease

Identifiers

PMID31214767
OpenAlexW2951306460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.