ArticleEuropean archives of psychiatry and clinical neuroscience2020
Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 15-year follow-up study.
Article in European archives of psychiatry and clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cognitive change 5+ years since the onset of a psychotic disorder: A systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- Placebo effects of repetitive transcranial magnetic stimulation on negative symptoms and cognition in patients with schizophrenia spectrum disorders: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions.Archives of women's mental health · 2026Trial
- Effects of multitask training on cognition and motor control in people with schizophrenia spectrum disorders.PloS one · 2022Trial
- Memory and learning impairments in deficit and non-deficit schizophrenia: a scoping review.Postepy psychiatrii neurologii · 2026Review
- The relationship between inflammatory markers, clinical characteristics, and cognitive performance in drug-naïve patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Improving outcome of treatment-resistant schizophrenia: effects of cognitive remediation therapy.European archives of psychiatry and clinical neuroscience · 2024Article
- Patterns of Impaired Neurocognitive Performance on the Global Neuropsychological Assessment, and Their Brain Structural Correlates in Recent-onset and Chronic Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia.Scientific reports · 2021Article
- Verbal memory measurement towards digital perspectives in first-episode psychosis: A review.Schizophrenia research. Cognition · 2020Review
- [Cognitive disorders in schizophrenia].Der Nervenarzt · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
To evaluate the course of neuropsychological impairment, patients with first-episode schizophrenia and healthy controls were assessed with a comprehensive test battery at the time of index treatment and after a 5- and 15-year follow-up period. Summary scores for verbal intelligence (VBI), spatial organization, verbal fluency, verbal learning, semantic memory, visual memory, delay/retention rate, short-term memory, visual-motor processing and attention (VSM) and abstraction/flexibility were constructed. Our results show that neurocognitive functioning is impaired already at the onset of schizophrenia and remains stable over the 15-year follow-up period with an improvement in VBI. With regard to the presence of a deficit syndrome, it became apparent that the group with a deficit syndrome showed a deterioration of neurocognitive functions during the follow-up period, most pronounced in VSM. On the other hand, the group without a deficit syndrome showed an improvement in neurocognitive functions at the 15-year follow-up, which exceeded the learning effects of healthy control subjects. Neurocognitive performance at index assessment strongly predicted the performance at the 15-year follow-up. Most likely due to the small sample size, there were only weak associations between treatment with different types of neuroleptics and neurocognitive performance.
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Registered trials
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