Evidence map›Paper›PMID 31214750›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019

Saving bones without risking brain-bisphosphonates and risk of stroke: matched case-control study.

Z B Asghar, A Godoy Caballero, S Pathirannehelage, J Williams, S McKay, P Grassby, S de Lusignan, A Niroshan Siriwardena

Abstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 3 citations in OpenAlex.

  1. Association between bisphosphonate use and stroke risk: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Z B AsgharMathematical Modelling and Statistics, Community and Health Research Unit, School of Health and Social Care, College of Social Science, University of Lincoln, Brayford Campus, Lincoln, LN6 7TS, UK. zasghar@lincoln.ac.uk.ORCID http://orcid.org/0000-0003-2564-2096
A Godoy CaballeroCommunity and Health Research Unit, School of Health and Social Care, College of Social Science, University of Lincoln, Brayford Campus, Lincoln, LN6 7TS, UK.
S PathirannehelageSection of Clinical Medicine and Ageing, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, GU2 7XH, UK.
J WilliamsSection of Clinical Medicine and Ageing, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, GU2 7XH, UK.
S McKaySchool of Social and Political Sciences, College of Social Science, School of Social Policy, CSS, University of Lincoln, Brayford Campus, Lincoln, LN6 7TS, UK.
P GrassbySchool of Pharmacy, College of Science, University of Lincoln, Brayford Campus, Lincoln, LN6 7TS, UK.
S de LusignanPrimary Care and Clinical Informatics, Nuffield Department of Primary Care Health Sciences, Medical Sciences Division, Radcliffe Observatory Quarter, University of Oxford, Woodstock Road, Oxford, OX2 6GG, UK.
A Niroshan SiriwardenaPrimary & Pre-Hospital Health Care, Community and Health Research Unit, School of Health and Social Care, College of Social Science, University of Lincoln, Brayford Campus, Lincoln, LN6 7TS, UK.
University of Lincoln · GBUniversity of Surrey · GBUniversity of Oxford · GB

Funding

University of Lincoln Research Investment Fund Grant RIF2013-51
6 · The paper itself

Abstract

We investigated the association between bisphosphonate treatment and the risk of stroke using a large routine clinical dataset. We found no association between bisphosphonate treatment and risk of stroke, after adjusting for large number of clinical and demographic confounders.

introductionThere is conflicting evidence on the link between bisphosphonates and stroke with studies variously showing increased, decreased or unchanged risk. We investigated the association between bisphosphonate treatment and the risk of stroke using a large routine clinical dataset.

methodsWe used a matched nested case-control study design analysing routinely collected electronic data from patients registered at primary care practices in England participating in the Royal College of General Practitioners Research and Surveillance Centre. Cases were patients aged 18 years or over, either living or dead, recorded as having had a stroke in the period 1 January 2005 to 31 March 2016. Each case was matched to one control according to age, sex, general practice attended and calendar time. Data were analysed using Stata, version 14.2. and RStudio, version 1.1.463. Conditional logistic regression was used to determine odds ratios for stroke according to bisphosphonate treatment and duration in cases compared with controls. We adjusted for disease risk groups, cardiovascular risk factors, treatments, smoking status, alcohol consumption, ethnicity, bisphosphonate types, fracture and socioeconomic status using IMD (Index of Multiple Deprivation).

resultsWe included 31,414 cases of stroke with an equal number of matched controls. Overall, 83.2% of cases and controls were aged 65 years or older, and there were similar proportions of females (51.5%) and males (48.5%). Bisphosphonate treatment was not associated with stroke after adjusting for the wide range of confounders considered (OR 0.86, 95% CI 0.62-1.19).

conclusionsWe found no association between bisphosphonate treatment and risk of stroke, after adjusting for other confounders.

Indexed as

AdolescentAdultAgedBone Density Conservation AgentsCase-Control StudiesDiphosphonatesElectronic Health RecordsEnglandFemaleHumansMaleMiddle AgedOsteoporosisOsteoporotic FracturesRisk FactorsStrokeBone Density Conservation AgentsDiphosphonatesBisphosphonatesElectronic clinical-patient datasetFractureNested matched case-control studyONJStroke

Identifiers

PMID31214750
OpenAlexW2951200748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.