Evidence map›Paper›PMID 31214731›Full record

SynthesisPediatric cardiology2019

Surgical Outcomes in Syndromic Tetralogy of Fallot: A Systematic Review and Evidence Quality Assessment.

Dimitrios I Athanasiadis, Konstantinos S Mylonas, Karampet Kasparian, Ioannis A Ziogas, Dimitra Vlachopoulou, Panagiotis G Sfyridis, Dimitrios Schizas, Eleftherios Spartalis, Nikolaos Nikiteas, Pouya Hemmati and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Health-related quality of life in adults with tetralogy of Fallot repair: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
  2. Molecular syndromology · 2026
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dimitrios I AthanasiadisPediatric Cardiac Surgery and Pediatric Cardiology Working Group, Society of Junior Doctors, Athens, Greece.
Konstantinos S MylonasPediatric Cardiac Surgery and Pediatric Cardiology Working Group, Society of Junior Doctors, Athens, Greece. ksmylonas@gmail.com.ORCID http://orcid.org/0000-0002-2356-6694
Karampet KasparianPediatric Cardiac Surgery and Pediatric Cardiology Working Group, Society of Junior Doctors, Athens, Greece.
Ioannis A ZiogasPediatric Cardiac Surgery and Pediatric Cardiology Working Group, Society of Junior Doctors, Athens, Greece.
Dimitra VlachopoulouSchool of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Panagiotis G SfyridisDepartment of Pediatric Cardiac Surgery, Mitera Children'S Hospital, Athens, Greece.
Dimitrios Schizas1st Department of Surgery, Laikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Eleftherios SpartalisLaboratory of Experimental Surgery and Surgical Research, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos NikiteasLaboratory of Experimental Surgery and Surgical Research, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Pouya HemmatiDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Afksendiyos KalangosDepartment of Pediatric Cardiac Surgery, Mitera Children'S Hospital, Athens, Greece.
Dimitrios V AvgerinosDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York City, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetralogy of Fallot (ToF) is one of the most common cyanotic congenital heart defects. We sought to summarize all available data regarding the epidemiology and perioperative outcomes of syndromic ToF patients. A PRISMA-compliant systematic literature review of PubMed and Cochrane Library was performed. Twelve original studies were included. The incidence of syndromic ToF was 15.3% (n = 549/3597). The most prevalent genetic syndromes were 22q11.2 deletion (47.8%; 95% CI 43.4-52.2) and trisomy 21 (41.9%; 95% CI 37.7-46.3). Complete surgical repair was performed in 75.2% of the patients (n = 161/214; 95% CI 69.0-80.1) and staged repair in 24.8% (n = 53/214; 95 CI 19.4-30.9). Relief of RVOT obstruction was performed with transannular patch in 64.7% (n = 79/122; 95% CI 55.9-72.7) of the patients, pulmonary valve-sparing technique in 17.2% (n = 21/122; 95% CI 11.5-24.9), and RV-PA conduit in 18.0% (n = 22/122; 95% CI 12.1-25.9). Pleural effusions were the most common postoperative complications (n = 28/549; 5.1%; 95% CI 3.5-7.3). Reoperations were performed in 4.4% (n = 24/549; 95% CI 2.9-6.4) of the patients. All-cause mortality rate was 9.8% (n = 51/521; 95% CI 7.5-12.7). Genetic syndromes are seen in approximately 15% of ToF patients. Long-term survival exceeds 90%, suggesting that surgical management should be dictated by anatomy regardless of genetics.

Indexed as

Cardiac Surgical ProceduresDiGeorge SyndromeDown SyndromeFemaleHumansIncidenceInfantInfant, NewbornMalePostoperative ComplicationsPulmonary ValveReoperationRetrospective StudiesTetralogy of FallotTreatment OutcomeCardiac surgeryGene mutationGeneticsTetralogy of FallotTOF

Identifiers

PMID31214731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.